Crizotinib

← predicts response to

ROS1 Fusionfusion

4 source records aggregated

sensitivity

Curated

Anaplastic Large Cell Lymphoma,Inflammatory Myofibroblastic Tumor,Lung Non-Small Cell Carcinoma+1

← predicts response to

ALK Fusionfusion

9 source records aggregated

sensitivity

Curated

← predicts response to

MET Exon 14 Skipping Mutationdeletion_cna

sensitivity

Curated

← predicts response to

ROS1 Fusionfusion

sensitivity

Curated

← predicts response to

AREG Expressionexpression

resistance

Curated

← predicts response to

ALK Fusionfusion

sensitivity

Curated

← predicts response to

ALK Fusionfusion

13 source records aggregated

resistance

Curated

Glioblastoma,Lung Adenocarcinoma,Lung Non-Small Cell Carcinoma+3

← predicts response to

MET Amplificationamplification

9 source records aggregated

sensitivity

Curated

← predicts response to

MET Exon 14 Skipping Mutationdeletion_cna

6 source records aggregated

sensitivity

Curated

Anaplastic Large Cell Lymphoma,Diffuse Large B-Cell Lymphoma,Lung Adenocarcinoma+2

← predicts response to

ALK Fusionfusion

6 source records aggregated

sensitivity

Curated

← predicts response to

ROS1 G2032RSNV

3 source records aggregated

resistance

Curated

← predicts response to

ALK G1269ASNV

3 source records aggregated

resistance

Curated

← predicts response to

ALK C1156YSNV

3 source records aggregated

resistance

Curated

← predicts response to

ALK Fusionfusion

3 source records aggregated

sensitivity

Curated

Crizotinib targets …TARGETS6 of 6
→ targets	MST1R	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	ROS1	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	NPM1	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	EML4	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	ALK	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	MET	—	INHIBITOR	—	1	Curated	chembl	graph →

Crizotinib targets …TARGETS6 of 6

→ targets

MST1R

—

INHIBITOR

—

Curated

→ targets

ROS1

—

INHIBITOR

—

Curated

→ targets

NPM1

—

INHIBITOR

—

Curated

→ targets

EML4

—

INHIBITOR

—

Curated

→ targets

ALK

—

INHIBITOR

—

Curated

→ targets

MET

—

INHIBITOR

—

Curated

Crizotinib investigated for …INVESTIGATED_FOR53 of 53show fewer
→ investigated for	Lung Non-Small Cell Carcinomasubtype 7 source records aggregated	supports	A	Lung Non-Small Cell Carcinoma	7	Curated	civic	graph →
→ investigated for	Inflammatory Myofibroblastic Tumorsubtype	supports	A	Inflammatory Myofibroblastic Tumor	1	Curated	civic	graph →
→ investigated for	Anaplastic Large Cell Lymphomahematologic_malignancy	supports	A	Anaplastic Large Cell Lymphoma	1	Curated	civic	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype 7 source records aggregated	supports	B	Lung Non-Small Cell Carcinoma	7	Curated	civic	graph →
→ investigated for	Inflammatory Myofibroblastic Tumorsubtype 2 source records aggregated	supports	B	Inflammatory Myofibroblastic Tumor	2	Curated	civic	graph →
→ investigated for	Anaplastic Large Cell Lymphomahematologic_malignancy 2 source records aggregated	supports	B	Anaplastic Large Cell Lymphoma	2	Curated	civic	graph →
→ investigated for	Malignant Neoplasmcancer_family	supports	B	Malignant Neoplasm	1	Curated	civic	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	4	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype 22 source records aggregated	supports	C	Lung Non-Small Cell Carcinoma	22	Curated	civic	graph →
→ investigated for	Lung Adenocarcinomasubtype 16 source records aggregated	supports	C	Lung Adenocarcinoma	16	Curated	civic	graph →
→ investigated for	Neuroblastomasubtype 3 source records aggregated	supports	C	Neuroblastoma	3	Curated	civic	graph →
→ investigated for	Inflammatory Myofibroblastic Tumorsubtype 3 source records aggregated	supports	C	Inflammatory Myofibroblastic Tumor	3	Curated	civic	graph →
→ investigated for	Diffuse Large B-Cell Lymphomahematologic_malignancy 2 source records aggregated	supports	C	Diffuse Large B-Cell Lymphoma	2	Curated	civic	graph →
→ investigated for	Malignant Neoplasmcancer_family 2 source records aggregated	supports	C	Malignant Neoplasm	2	Curated	civic	graph →
→ investigated for	Vaginal Sarcomasubtype	supports	C	Vaginal Sarcoma	1	Curated	civic	graph →
→ investigated for	Lung Squamous Cell Carcinomasubtype	supports	C	Lung Squamous Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Infantile Fibrosarcomasubtype	supports	C	Infantile Fibrosarcoma	1	Curated	civic	graph →
→ investigated for	Malignant Head and Neck Neoplasmcancer_family	supports	C	Malignant Head and Neck Neoplasm	1	Curated	civic	graph →
→ investigated for	Thyroid Gland Anaplastic Carcinomasubtype	supports	C	Thyroid Gland Anaplastic Carcinoma	1	Curated	civic	graph →
→ investigated for	Glioblastomasubtype	supports	C	Glioblastoma	1	Curated	civic	graph →
→ investigated for	Minimally Invasive Lung Adenocarcinomasubtype	supports	C	Minimally Invasive Lung Adenocarcinoma	1	Curated	civic	graph →
→ investigated for	Cutaneous Melanomacancer	supports	C	Cutaneous Melanoma	1	Curated	civic	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype	supports	C	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ investigated for	Anaplastic Large Cell Lymphomahematologic_malignancy	supports	C	Anaplastic Large Cell Lymphoma	1	Curated	civic	graph →
→ investigated for	Carcinomacancer_family	unknown	3	Carcinoma	1	Curated	chembl	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	3	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Adenocarcinomasubtype	unknown	3	Lung Adenocarcinoma	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype 19 source records aggregated	supports	D	Lung Non-Small Cell Carcinoma	19	Curated	civic	graph →
→ investigated for	Malignant Neoplasmcancer_family 4 source records aggregated	supports	D	Malignant Neoplasm	4	Curated	civic	graph →
→ investigated for	Neuroblastomasubtype 3 source records aggregated	supports	D	Neuroblastoma	3	Curated	civic	graph →
→ investigated for	Lung Adenocarcinomasubtype 2 source records aggregated	supports	D	Lung Adenocarcinoma	2	Curated	civic	graph →
→ investigated for	Uveal Melanomasubtype	supports	D	Uveal Melanoma	1	Curated	civic	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype	supports	D	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ investigated for	Anaplastic Large Cell Lymphomahematologic_malignancy	supports	D	Anaplastic Large Cell Lymphoma	1	Curated	civic	graph →
→ investigated for	Gallbladder Neoplasmsubtype	unknown	2	Gallbladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Uveal Melanomasubtype	unknown	2	Uveal Melanoma	1	Curated	chembl	graph →
→ investigated for	Bile Duct Neoplasmsubtype	unknown	2	Bile Duct Neoplasm	1	Curated	chembl	graph →
→ investigated for	Multiple Myelomahematologic_malignancy	unknown	2	Multiple Myeloma	1	Curated	chembl	graph →
→ investigated for	Endometrial Neoplasmsubtype	unknown	2	Endometrial Neoplasm	1	Curated	chembl	graph →
→ investigated for	Gastric Neoplasmcancer_family	unknown	2	Gastric Neoplasm	1	Curated	chembl	graph →
→ investigated for	Anaplastic Large Cell Lymphomahematologic_malignancy	unknown	2	Anaplastic Large Cell Lymphoma	1	Curated	chembl	graph →
→ investigated for	Adenocarcinomahistology	unknown	2	Adenocarcinoma	1	Curated	chembl	graph →
→ investigated for	Squamous Cell Carcinomahistology	unknown	2	Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Acute Myeloid Leukemiahematologic_malignancy	unknown	2	Acute Myeloid Leukemia	1	Curated	chembl	graph →
→ investigated for	Renal Cell Carcinomasubtype	unknown	2	Renal Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Colorectal Adenocarcinomasubtype 2 source records aggregated	supports	E	Colorectal Adenocarcinoma	2	Curated	civic	graph →
→ investigated for	Malignant Breast Neoplasmcancer_family	supports	E	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	supports	E	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	1	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	1	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Diffuse Intrinsic Pontine Gliomasubtype	unknown	1	Diffuse Intrinsic Pontine Glioma	1	Curated	chembl	graph →
→ investigated for	Glioblastomasubtype	unknown	1	Glioblastoma	1	Curated	chembl	graph →

Crizotinib investigated for …INVESTIGATED_FOR53 of 53show fewer

→ investigated for

7 source records aggregated

supports

Curated

→ investigated for

supports

Curated

→ investigated for

Anaplastic Large Cell Lymphomahematologic_malignancy

supports

Curated

→ investigated for

7 source records aggregated

supports

Curated

→ investigated for

2 source records aggregated

supports

Curated

→ investigated for

Anaplastic Large Cell Lymphomahematologic_malignancy

2 source records aggregated

supports

Curated

→ investigated for

Malignant Neoplasmcancer_family

supports

Curated

→ investigated for

Neoplasmcancer_family

unknown

Neoplasm

Curated

→ investigated for

unknown

Curated

→ investigated for

22 source records aggregated

supports

Curated

→ investigated for

Lung Adenocarcinomasubtype

16 source records aggregated

supports

Lung Adenocarcinoma

Curated

→ investigated for

Neuroblastomasubtype

3 source records aggregated

supports

Neuroblastoma

Curated

→ investigated for

3 source records aggregated

supports

Curated

Diffuse Large B-Cell Lymphoma

→ investigated for

Diffuse Large B-Cell Lymphomahematologic_malignancy

2 source records aggregated

supports

Curated

→ investigated for

Malignant Neoplasmcancer_family

2 source records aggregated

supports

Curated

→ investigated for

Vaginal Sarcomasubtype

supports

Vaginal Sarcoma

Curated

Lung Squamous Cell Carcinoma

→ investigated for

Lung Squamous Cell Carcinomasubtype

supports

Curated

→ investigated for

Infantile Fibrosarcomasubtype

supports

Infantile Fibrosarcoma

Curated

Malignant Head and Neck Neoplasm

→ investigated for

Malignant Head and Neck Neoplasmcancer_family

supports

Curated

Thyroid Gland Anaplastic Carcinoma

→ investigated for

Thyroid Gland Anaplastic Carcinomasubtype

supports

Curated

→ investigated for

Glioblastomasubtype

supports

Glioblastoma

Curated

Minimally Invasive Lung Adenocarcinoma

→ investigated for

Minimally Invasive Lung Adenocarcinomasubtype

supports

Curated

→ investigated for

Cutaneous Melanomacancer

supports

Cutaneous Melanoma

Curated

Malignant Colorectal Neoplasm

→ investigated for

Malignant Colorectal Neoplasmsubtype

supports

Curated

→ investigated for

Anaplastic Large Cell Lymphomahematologic_malignancy

supports

Curated

→ investigated for

Carcinomacancer_family

unknown

Carcinoma

Curated

→ investigated for

Lung Neoplasmcancer_family

unknown

Lung Neoplasm

Curated

→ investigated for

Lung Adenocarcinomasubtype

unknown

Lung Adenocarcinoma

Curated

→ investigated for

19 source records aggregated

supports

Curated

→ investigated for

Malignant Neoplasmcancer_family

4 source records aggregated

supports

Curated

→ investigated for

Neuroblastomasubtype

3 source records aggregated

supports

Neuroblastoma

Curated

→ investigated for

Lung Adenocarcinomasubtype

2 source records aggregated

supports

Lung Adenocarcinoma

Curated

→ investigated for

Uveal Melanomasubtype

supports

Curated

Malignant Colorectal Neoplasm

→ investigated for

Malignant Colorectal Neoplasmsubtype

supports

Curated

→ investigated for

Anaplastic Large Cell Lymphomahematologic_malignancy

supports

Curated

→ investigated for

Gallbladder Neoplasmsubtype

unknown

Gallbladder Neoplasm

Curated

→ investigated for

Uveal Melanomasubtype

unknown

Curated

→ investigated for

Bile Duct Neoplasmsubtype

unknown

Bile Duct Neoplasm

Curated

→ investigated for

Multiple Myelomahematologic_malignancy

unknown

Multiple Myeloma

Curated

→ investigated for

Endometrial Neoplasmsubtype

unknown

Endometrial Neoplasm

Curated

→ investigated for

Gastric Neoplasmcancer_family

unknown

Gastric Neoplasm

Curated

→ investigated for

Anaplastic Large Cell Lymphomahematologic_malignancy

unknown

Curated

→ investigated for

Adenocarcinomahistology

unknown

Adenocarcinoma

Curated

→ investigated for

Squamous Cell Carcinomahistology

unknown

Squamous Cell Carcinoma

Curated

→ investigated for

Acute Myeloid Leukemiahematologic_malignancy

unknown

Acute Myeloid Leukemia

Curated

→ investigated for

Renal Cell Carcinomasubtype

unknown

Renal Cell Carcinoma

Curated

Colorectal Adenocarcinoma

→ investigated for

Colorectal Adenocarcinomasubtype

2 source records aggregated

supports

Curated

Malignant Breast Neoplasm

→ investigated for

Malignant Breast Neoplasmcancer_family

supports

Curated

→ investigated for

supports

Curated

→ investigated for

Colorectal Neoplasmsubtype

unknown

Colorectal Neoplasm

Curated

→ investigated for

Breast Neoplasmcancer_family

unknown

Breast Neoplasm

Curated

Diffuse Intrinsic Pontine Glioma

→ investigated for

Diffuse Intrinsic Pontine Gliomasubtype

unknown

Curated

→ investigated for

Glioblastomasubtype

unknown

Glioblastoma

Curated

Crizotinib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 70show all (up to 200)
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 46 trials (13 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	46	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasmcancer_family 8 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Lung Neoplasm 7 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Lung Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Solid Neoplasm 7 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Solid Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Multiple Myelomahematologic_malignancy 6 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Multiple Myeloma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphoma 5 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 5 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Hematopoietic and Lymphoid Cell Neoplasm 4 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Neoplasmcancer_family 4 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Uveal Melanomasubtype 4 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Uveal Melanoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Anaplastic Large Cell Lymphoma, ALK-Positive 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Anaplastic Large Cell Lymphoma, ALK-Positive	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Inflammatory Myofibroblastic Tumorsubtype 3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Inflammatory Myofibroblastic Tumor	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 3 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Adenocarcinomahistology 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adenocarcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	ALK-Positive Lung Non-Small Cell Carcinoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	ALK-Positive Lung Non-Small Cell Carcinoma	2	Observed	clinicaltrials	graph →

Crizotinib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 70show all (up to 200)

→ investigated in trials for

46 trials (13 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Malignant Neoplasmcancer_family

8 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Malignant Lung Neoplasm

7 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Lung Neoplasm

Observed

→ investigated in trials for

Malignant Solid Neoplasm

7 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Solid Neoplasm

Observed

→ investigated in trials for

Multiple Myelomahematologic_malignancy

6 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Multiple Myeloma

Observed

→ investigated in trials for

Lymphoma

5 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Lymphoma

Observed

→ investigated in trials for

Solid Neoplasm

5 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Solid Neoplasm

Observed

Hematopoietic and Lymphoid Cell Neoplasm

→ investigated in trials for

4 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Hematopoietic and Lymphoid Cell Neoplasm

Observed

→ investigated in trials for

Neoplasmcancer_family

4 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Neoplasm

Observed

→ investigated in trials for

Uveal Melanomasubtype

4 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Anaplastic Large Cell Lymphoma, ALK-Positive

→ investigated in trials for

3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Anaplastic Large Cell Lymphoma, ALK-Positive

Observed

→ investigated in trials for

3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Malignant Colorectal Neoplasm

→ investigated in trials for

Malignant Colorectal Neoplasmsubtype

3 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Adenocarcinomahistology

2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Adenocarcinoma

Observed

ALK-Positive Lung Non-Small Cell Carcinoma

→ investigated in trials for

2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

ALK-Positive Lung Non-Small Cell Carcinoma

Observed

Hematopoietic and Lymphoid Cell Neoplasm,Lymphoma,Malignant Solid Neoplasm+2

Crizotinib studied in …STUDIED_INderived10 of 100show all (up to 200)
→ studied in	NCT02465060Phase 2 · active not recruiting Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) · 100 trials list this drug (27 active)	—	—	Hematopoietic and Lymphoid Cell Neoplasm,Lymphoma,Malignant Solid Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT02194738NA · active not recruiting Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial) · 100 trials list this drug (27 active)	—	—	Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06140836Phase 3 · active not recruiting A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3) · 100 trials list this drug (27 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07816380Phase 3 · not yet recruiting A Phase III Study to Evaluate the Efficacy and Safety of JYP0322 in Previously Untreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer · 100 trials list this drug (27 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04439253Phase 2 · active not recruiting Testing Crizotinib as a Potential Targeted Treatment in Cancers With ROS1 Genetic Changes (MATCH-Subprotocol G) · 100 trials list this drug (27 active)	—	—	Hematopoietic and Lymphoid Cell Neoplasm,Lymphoma,Malignant Solid Neoplasm+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT04693468Phase 1 · recruiting Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial · 100 trials list this drug (27 active)	—	—	Malignant Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07804186Phase 3 · recruiting Study of Adjuvant Darovasertib and Crizotinib in Participants With Primary Non-metastatic Uveal Melanoma · 100 trials list this drug (27 active)	—	—	Uveal Melanoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03375242completed Safety and Efficacy of Xalkori ROS1 · 100 trials list this drug (27 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04603807Phase 3 · active not recruiting A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases · 100 trials list this drug (27 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02838420Phase 3 · completed A Study to Evaluate and Compare the Efficacy and Safety of Alectinib Versus Crizotinib and to Evaluate the Pharmacokinetics of Alectinib in Asian Participants With Treatment-Naive Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) · 100 trials list this drug (27 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →

Crizotinib studied in …STUDIED_INderived10 of 100show all (up to 200)

→ studied in

NCT02465060Phase 2 · active not recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) · 100 trials list this drug (27 active)

—

Observed

Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma

→ studied in

NCT02194738NA · active not recruiting

Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial) · 100 trials list this drug (27 active)

—

Observed

→ studied in

NCT06140836Phase 3 · active not recruiting

A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3) · 100 trials list this drug (27 active)

—

Observed

→ studied in

NCT07816380Phase 3 · not yet recruiting

A Phase III Study to Evaluate the Efficacy and Safety of JYP0322 in Previously Untreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer · 100 trials list this drug (27 active)

—

Observed

Hematopoietic and Lymphoid Cell Neoplasm,Lymphoma,Malignant Solid Neoplasm+1

→ studied in

NCT04439253Phase 2 · active not recruiting

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ROS1 Genetic Changes (MATCH-Subprotocol G) · 100 trials list this drug (27 active)

—

Observed

→ studied in

NCT04693468Phase 1 · recruiting

Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial · 100 trials list this drug (27 active)

—

Malignant Solid Neoplasm

Observed

→ studied in

NCT07804186Phase 3 · recruiting

Study of Adjuvant Darovasertib and Crizotinib in Participants With Primary Non-metastatic Uveal Melanoma · 100 trials list this drug (27 active)

—

Observed

→ studied in

NCT03375242completed

Safety and Efficacy of Xalkori ROS1 · 100 trials list this drug (27 active)

—

Observed

→ studied in

NCT04603807Phase 3 · active not recruiting

A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases · 100 trials list this drug (27 active)

—

Observed

→ studied in

NCT02838420Phase 3 · completed

A Study to Evaluate and Compare the Efficacy and Safety of Alectinib Versus Crizotinib and to Evaluate the Pharmacokinetics of Alectinib in Asian Participants With Treatment-Naive Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) · 100 trials list this drug (27 active)

—

not mapped

Observed