Buparlisib

small molecule

Identifier: CI-DRUG-00000116
Entity page: /drug/buparlisib ↗
Edges: 162

Neighbours: 33 cancers8 genes1 variants10 trials
Drawn: 52 of 52 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Buparlisib predicts response to …PREDICTS_RESPONSE_TO1 of 1
← predicts response to	PTEN Lossdeletion_cna	sensitivity	C	Malignant Neoplasm	1	Curated	civic	graph →
Buparlisib targets …TARGETS8 of 8
→ targets

Buparlisib investigated for …INVESTIGATED_FOR24 of 24show fewer
→ investigated for	Malignant Neoplasmcancer_family	supports	C	Malignant Neoplasm	1	Curated	civic	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	3	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Head and Neck Neoplasmcancer_family	unknown	3	Head and Neck Neoplasm	1	Curated	chembl	graph →
→ investigated for	Endometrial Neoplasmsubtype	unknown	2	Endometrial Neoplasm	1	Curated	chembl	graph →
→ investigated for	Esophageal Neoplasmcancer_family	unknown	2	Esophageal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Thyroid Gland Neoplasmsubtype	unknown	2	Thyroid Gland Neoplasm	1	Curated	chembl	graph →
→ investigated for	Cervical Neoplasmsubtype	unknown	2	Cervical Neoplasm	1	Curated	chembl	graph →
→ investigated for	Squamous Cell Carcinomahistology	unknown	2	Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	2	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Melanomacancer_family	unknown	2	Melanoma	1	Curated	chembl	graph →
→ investigated for	Glioblastomasubtype	unknown	2	Glioblastoma	1	Curated	chembl	graph →
→ investigated for	Chronic Lymphocytic Leukemiahematologic_malignancy	unknown	2	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	2	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Mantle Cell Lymphomahematologic_malignancy	unknown	2	Mantle Cell Lymphoma	1	Curated	chembl	graph →
→ investigated for	Thymomasubtype	unknown	2	Thymoma	1	Curated	chembl	graph →
→ investigated for	Lymphoid Leukemiahematologic_malignancy	unknown	1	Lymphoid Leukemia	1	Curated	chembl	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	1	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	1	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Gastrointestinal Stromal Tumorsubtype	unknown	1	Gastrointestinal Stromal Tumor	1	Curated	chembl	graph →
→ investigated for	Primary Myelofibrosishematologic_malignancy	unknown	1	Primary Myelofibrosis	1	Curated	chembl	graph →
→ investigated for	Follicular Lymphomahematologic_malignancy	unknown	1	Follicular Lymphoma	1	Curated	chembl	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	1	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	1	Leukemia	1	Curated	chembl	graph →
→ investigated for	Lung Small Cell Carcinomasubtype	unknown	1	Lung Small Cell Carcinoma	1	Curated	chembl	graph →

Buparlisib investigated for …INVESTIGATED_FOR24 of 24show fewer

→ investigated for

Malignant Neoplasmcancer_family

supports

Malignant Neoplasm

Curated

Buparlisib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 57show all (up to 200)
→ investigated in trials for	Malignant Breast Neoplasm 17 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 6 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasm 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Neoplasmcancer_family 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Glioblastomasubtype 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Glioblastoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Endometrial Neoplasm 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Endometrial Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Solid Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Solid Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Prostate Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Prostate Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Mantle Cell Lymphomahematologic_malignancy 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Mantle Cell Lymphoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Lymphocytic Leukemiahematologic_malignancy 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Lymphocytic Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Diffuse Large B-Cell Lymphoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Diffuse Large B-Cell Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Grade 3 Follicular Lymphoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Grade 3 Follicular Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphomacancer_family 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Lung Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Lung Neoplasm	2	Observed	clinicaltrials	graph →

Buparlisib studied in …STUDIED_INderived10 of 72show all (up to 200)
→ studied in	NCT01339052Phase 2 · completed Phase II Study of BKM120 for Subjects With Recurrent Glioblastoma · 72 trials list this drug (0 active)	—	—	Glioblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04975958Phase 1 · completed Double/Triple Combinations of AN2025, AN0025 and Atezolizumab in Advanced Solid Tumors · 72 trials list this drug (0 active)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02113878Phase 1 · completed Phase Ib Study of BKM120 With Cisplatin and XRT in High Risk Locally Advanced Squamous Cell Cancer of Head and Neck · 72 trials list this drug (0 active)	—	—	Carcinoma,Laryngeal Carcinoma,Malignant Hypopharyngeal Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT02159066Phase 2 · completed LGX818 and MEK162 in Combination With a Third Agent (BKM120, LEE011, BGJ398 or INC280) in Advanced BRAF Melanoma · 72 trials list this drug (0 active)	—	—	Melanoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01397877Phase 2 · completed GINECO-EN102b - BKM120 as Monotherapy in the Treatment of Initial or Recurrent Metastatic Endometrial Cancer · 72 trials list this drug (0 active)	—	—	Malignant Endometrial Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02340780Phase 2 · completed Buparlisib in Patients With Relapsed and Refractory Chronic Lymphocytic Leukemia · 72 trials list this drug (0 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01591421Phase 1/Phase 2 · completed P13Kinase Inhibitor BKM120 in Combination With Panitumumab in Metastatic/Advanced RAS-Wild Type Colorectal Cancer. · 72 trials list this drug (0 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT01971489Phase 1 · withdrawn Buparlisib, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Advanced Solid Tumors · 72 trials list this drug (0 active)	—	—	Adult Solid Neoplasm,Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02756247Phase 1 · completed A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma · 72 trials list this drug (0 active)	—	—	Lymphoma,Diffuse Large B-Cell Lymphoma,Follicular Lymphoma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT02117817Phase 1 · withdrawn Phase I BKM120/Abraxane in Solid Tumors, Expansion Phase Recurrent Endometrial or Ovarian Cancer · 72 trials list this drug (0 active)	—	—	Malignant Ovarian Neoplasm,Malignant Endometrial Neoplasm	1	Observed	clinicaltrials	graph →

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