Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1

Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

5 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RUNX1T1 Fusion5
(prognostic)	Prognostic	A	Supports Better Outcome	5	accepted	EID11881 This study evaluated the independent prognostic significance of pretreatment cytogenetics based on the large Medical Research Council (MRC) AML 10 trial which enrolled a total of 1,966 patients (364 c… (full text at CIViC) PMID 9746770 · Grimwade et al., 1998 · Open in CIViC	civic
(diagnostic)	Diagnostic	A	Supports Positive	4	accepted	EID11880 This study evaluated the independent prognostic significance of pretreatment cytogenetics based on the large Medical Research Council (MRC) AML 10 trial which enrolled a total of 1,966 patients (364 c… (full text at CIViC) PMID 9746770 · Grimwade et al., 1998 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID11878 In this 1992 study, the authors isolated a clone containing the junction region of the (8;21)(q22;q22) translocation characteristic for acute myeloid leukemia with t(8;21). Using probes from the junct… (full text at CIViC) PMID 1391946 · Erickson et al., 1992 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID11879 The researchers analyzed immunophenotype in 30 cases of newly diagnosed pediatric acute myeloid leukemia (AML) exhibiting M2 morphology per French-American-British classification. They correlated thes… (full text at CIViC) PMID 1467524 · Hurwitz et al., 1992 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	3	accepted	EID11882 The authors of this 1997 paper compared morphologic and cytochemical features between 30 acute myeloid leukemia subtype M2 (AML-M2) patients with t(8;21) and 50 AML-M2 patients without t(8;21). Morp… (full text at CIViC) PMID 9180287 · Nakamura et al., 1997 · Open in CIViC	civic

Data updated 23 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.