Publication
Recurrent PTPRB and PLCG1 mutations in angiosarcoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerAngiosarcomacivic_curation1.00
- drugSunitinibcivic_curation1.00
- drugVatalanibcivic_curation1.00
- genePTPRBcivic_curation1.00
- variantPTPRB Loss-of-functioncivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24633157
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PTPRB Loss-of-function2 | ||||||||
| (diagnostic) | Angiosarcoma | Diagnostic | B | Supports Positive | 3 | accepted | EID10079A cohort of angiosarcomas (n=36) was sequenced and revealed to contain recurrent mutations in PTPRB (10/36) which were predominantly truncating or splice variants which impact the tyrosine phosphotase… (full text at CIViC) PMID 24633157 · Behjati et al., 2014 · Open in CIViC | civic |
| Sunitinib + VatalanibSubstitutes | Angiosarcoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1895The endothelial phosphatase PTPRB, a negative regulator of vascular growth factor tyrosine kinases, harbored truncating mutations in 10 of 39 angiosarcomas (26%) which correlated with MYC amplificatio… (full text at CIViC) PMID 24633157 · Behjati et al., 2014 · Open in CIViC | civic |
| PTPRB W130R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | E | Supports Loss Of Function | 1 | submitted | EID10081A cohort of angiosarcomas (n=36) was sequenced and revealed to contain recurrent mutations in PTPRB (10/36) which were predominantly truncating or splice variants impacting the tyrosine phosphotase do… (full text at CIViC) PMID 24633157 · Behjati et al., 2014 · Open in CIViC | civic |
| PTPRB Y309C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | E | Supports Loss Of Function | 1 | submitted | EID10080A cohort of angiosarcomas (n=36) was sequenced and revealed to contain recurrent mutations in PTPRB (10/36) which were predominantly truncating or splice variants impacting the tyrosine phosphotase do… (full text at CIViC) PMID 24633157 · Behjati et al., 2014 · Open in CIViC | civic |