Acute Myeloid Leukemia with NUP98 Rearrangement — Variants & evidence

Acute Myeloid Leukemia with NUP98 Rearrangement — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NUP98 Fusion4
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12377 In this 2016 study the authors included 153 pediatric non-Down syndrome patients diagnosed with acute megakaryoblastic leukemia (AMKL) which is a rare subtype of acute myeloid leukemia. All patients w… (full text at CIViC) PMID 27114462 · de Rooij et al., 2016 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12378 In this 2011 study the authors included pediatric and adult cohorts of patients diagnosed with acute myeloid leukemia (AML). Initially, using RT-PCR, they detected the cytogenetically cryptic NUP98::N… (full text at CIViC) PMID 21813447 · Hollink et al., 2011 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12379 In this 2014 study the authors investigated the presence of NUP98::NSD1 fusion in pediatric and adult acute myeloid leukemia (AML) patients. Utilizing reverse transcriptase-polymerase chain reaction (… (full text at CIViC) PMID 25145343 · Ostronoff et al., 2014 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12380 In this 2023 study the authors included 2,235 children and young adults diagnosed with acute myeloid leukemia (AML). NUP98 fusions were detected in these patients either by karyotype of RNA sequencing… (full text at CIViC) PMID 36815378 · Bertrums et al., 2023 · Open in CIViC	civic

Data updated 21 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.