Publication
Recurrent abnormalities can be used for risk group stratification in pediatric AMKL: a retrospective intergroup study.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerAcute Myeloid Leukemia with NUP98 Rearrangementcivic_curation1.00
- geneNUP98civic_curation1.00
- variantNUP98 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27114462
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KDM5A Fusion1 | ||||||||
| (prognostic) | Acute Megakaryoblastic LeukemiaALIAS | Prognostic | B | Supports Poor Outcome | 4 | submitted | EID8502Acute megakaryoblastic leukemia (AMKL) is a rare subtype of AML. CBFA2T3/GLIS2 and NUP98/KDM5A are recurrent aberrations, occurring in similar frequencies as RBM15/MKL1 and KMT2A-rearrangements. In th… (full text at CIViC) PMID 27114462 · de Rooij et al., 2016 · Open in CIViC | civic |
| MRTFA Fusion1 | ||||||||
| (prognostic) | Acute Megakaryoblastic LeukemiaALIAS | Prognostic | B | Supports Better Outcome | 4 | submitted | EID8514In this manuscript, data and clinical samples from 153 newly diagnosed non-Down syndrome pediatric AMKL cases were analyzed. Patients samples were screened for the recurrent molecular aberrations in N… (full text at CIViC) PMID 27114462 · de Rooij et al., 2016 · Open in CIViC | civic |
| NUP98 Fusion1 | ||||||||
| (diagnostic) | Acute Myeloid Leukemia with NUP98 Rearrangement | Diagnostic | B | Supports Positive | 4 | accepted | EID12377In this 2016 study the authors included 153 pediatric non-Down syndrome patients diagnosed with acute megakaryoblastic leukemia (AMKL) which is a rare subtype of acute myeloid leukemia. All patients w… (full text at CIViC) PMID 27114462 · de Rooij et al., 2016 · Open in CIViC | civic |
| GLIS2 Fusion1 | ||||||||
| (prognostic) | Childhood Acute Megakaryoblastic Leukemia | Prognostic | B | Supports Poor Outcome | 4 | submitted | EID8503Acute megakaryoblastic leukemia (AMKL) is a rare subtype of AML. CBFA2T3/GLIS2 and NUP98/KDM5A are recurrent aberrations, occurring in similar frequencies as RBM15/MKL1 and KMT2A-rearrangements. In th… (full text at CIViC) PMID 27114462 · de Rooij et al., 2016 · Open in CIViC | civic |