Publication
NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerAcute Myeloid Leukemia with NUP98 Rearrangementcivic_curation1.00
- geneNUP98civic_curation1.00
- variantNUP98 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25145343
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NSD1 Fusion1 | ||||||||
| (prognostic) | Acute Myeloid LeukemiaCURATED_BROADER | Prognostic | B | Supports Poor Outcome | 3 | submitted | EID7054This publication examines coexpression of NUP98/NSD1 and FLT3/ITD in AML, remission, and survival rate in 1421 patients. The CR rate for patients with and without FLT3/ITD was 63% and 82%, respectivel… (full text at CIViC) PMID 25145343 · Ostronoff et al., 2014 · Open in CIViC | civic |
| NUP98 Fusion1 | ||||||||
| (diagnostic) | Acute Myeloid Leukemia with NUP98 Rearrangement | Diagnostic | B | Supports Positive | 4 | accepted | EID12379In this 2014 study the authors investigated the presence of NUP98::NSD1 fusion in pediatric and adult acute myeloid leukemia (AML) patients. Utilizing reverse transcriptase-polymerase chain reaction (… (full text at CIViC) PMID 25145343 · Ostronoff et al., 2014 · Open in CIViC | civic |