Publication
Pediatric low-grade gliomas can be molecularly stratified for risk.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (14)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 14
- cancerChildhood Low Grade Gliomacivic_curation1.00
- geneATRXcivic_curation1.00
- geneBRAFcivic_curation1.00
- geneCDKN2Acivic_curation1.00
- geneH3-3Acivic_curation1.00
- geneMYBcivic_curation1.00
- geneTERTcivic_curation1.00
- variantATRX Underexpressioncivic_curation1.00
- variantBRAF Fusioncivic_curation1.00
- variantBRAF V600Ecivic_curation1.00
- variantCDKN2A Deletioncivic_curation1.00
- variantH3-3A MUTATIONcivic_curation1.00
- variantMYB AMPLIFICATIONcivic_curation1.00
- variantTERT Promoter Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (7)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 29948154
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ATRX Underexpression1 | ||||||||
| (prognostic) | Childhood Low Grade Glioma | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID7190Loss of ATRX was identified in 12 of 247 patients with PLGGs using immunohistochemistry. Survival analysis showed that ATRX loss was associated with adverse overall survival (p<0.0001) and progression… (full text at CIViC) PMID 29948154 · Yang et al., 2018 · Open in CIViC | civic |
| BRAF V600E1 | ||||||||
| (prognostic) | Childhood Low Grade Glioma | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID7191Using Sanger sequencing, BRAFV600E mutations were identified in 21 of 285 patients with PLGGs (7.4%). This mutation was enriched in hemispheric tumors (p<0.007) and was associated with shorter progres… (full text at CIViC) PMID 29948154 · Yang et al., 2018 · Open in CIViC | civic |
| CDKN2A Deletion1 | ||||||||
| (prognostic) | Childhood Low Grade Glioma | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID7192CDKN2A deletion was identified in 24 of 273 patients with PLGGs using FISH analysis. An association between this alteration and BRAFV600E was detected (p=0.0001). Hemispheric tumors with CDKN2A deleti… (full text at CIViC) PMID 29948154 · Yang et al., 2018 · Open in CIViC | civic |
| H3-3A MUTATION1 | ||||||||
| (prognostic) | Childhood Low Grade Glioma | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID7189Using Sanger sequencing, H3F3A mutations in patients with pediatric low-grade gliomas (PLGGs) were identified (K27M: 13/280; G34R: 5/280). Kaplan-Meier survival analysis showed that H3F3A mutations we… (full text at CIViC) PMID 29948154 · Yang et al., 2018 · Open in CIViC | civic |
| BRAF Fusion1 | ||||||||
| (prognostic) | Childhood Low Grade Glioma | Prognostic | B | Supports Better Outcome | 4 | accepted | EID7193KIAA1549-BRAF fusion was identified in 87 of 272 patients with PLGGs using Fluorescence In situ hybridization (FISH) analysis. This mutation was strongly associated with a greater progression-free sur… (full text at CIViC) PMID 29948154 · Yang et al., 2018 · Open in CIViC | civic |
| MYB AMPLIFICATION1 | ||||||||
| (prognostic) | Childhood Low Grade Glioma | Prognostic | B | Supports Better Outcome | 4 | accepted | EID7194MYB amplification was detected in 28 of 263 patients with PLGGs using Fluorescence In situ hybridization (FISH) analysis. The amplification of MYB was strongly associated with greater progression-free… (full text at CIViC) PMID 29948154 · Yang et al., 2018 · Open in CIViC | civic |
| TERT Promoter Mutation1 | ||||||||
| (prognostic) | Childhood Low Grade Glioma | Prognostic | C | Supports Poor Outcome | 4 | accepted | EID7188The aim of this Chinese study was to identify prognostic biomarkers for pediatric low-grade gliomas (PLGG). Approximately 300 patients were included. Using Sanger sequencing, mutations at TERT promote… (full text at CIViC) PMID 29948154 · Yang et al., 2018 · Open in CIViC | civic |