Publication

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

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Acta Neuropathol2020PMID 31563982PMC7477753stubpubmedPublished

Abstract

Abstract (excerpt)

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Linked entities

Linked entities (5)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 5

cancerDiffuse Astrocytomacivic_curation1.00
geneMYBcivic_curation1.00
geneMYBL1civic_curation1.00
variantMYBL1 Rearrangementcivic_curation1.00
variantMYB Rearrangementcivic_curation1.00

Curated evidence

Evidence citing this paper (2)

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MYBL1 Rearrangement1
(diagnostic)	Diffuse AstrocytomaALIAS	Diagnostic	B	Supports Positive	4	accepted	EID11780 Histological, molecular, and clinical analysis of 26 histologically prototypical isomorphic diffuse gliomas with a specific DNA methylation profile distinct from other glial/glio-neuronal brain tumors… (full text at CIViC) PMID 31563982 · Wefers et al., 2020 · Open in CIViC	civic
MYB Rearrangement1
(diagnostic)	Isomorphic Diffuse GliomaUNRESOLVED	Diagnostic	C	Supports Positive	3	accepted	EID11776 Histological, molecular, and clinical analysis of 26 histologically prototypical isomorphic diffuse gliomas with a specific DNA methylation profile distinct from other glial/glio-neuronal brain tumors… (full text at CIViC) PMID 31563982 · Wefers et al., 2020 · Open in CIViC	civic