Publication
Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerAngiocentric Gliomacivic_curation1.00
- cancerDiffuse Astrocytomacivic_curation1.00
- geneMYBcivic_curation1.00
- geneMYBL1civic_curation1.00
- variantMYBL1 Rearrangementcivic_curation1.00
- variantMYB Rearrangementcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23633565
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MYB Rearrangement1 | ||||||||
| (diagnostic) | Angiocentric Glioma | Diagnostic | C | Supports Positive | 2 | accepted | EID11774Copy-number analysis was performed on 44 diffuse pediatric low-grade gliomas (PLGGs) to identify recurrent alterations. The most significant event, focal 8q13.1 gain, was observed in 28% (5/18) of dif… (full text at CIViC) PMID 23633565 · Ramkissoon et al., 2013 · Open in CIViC | civic |
| MYBL1 Rearrangement1 | ||||||||
| (diagnostic) | Diffuse AstrocytomaALIAS | Diagnostic | B | Supports Positive | 4 | accepted | EID11781Copy-number analysis was performed on 44 diffuse pediatric low-grade gliomas (PLGGs) to identify recurrent alterations. The most significant event, focal 8q13.1 gain, was observed in 28% (5/18) of dif… (full text at CIViC) PMID 23633565 · Ramkissoon et al., 2013 · Open in CIViC | civic |