FAT1

FAT atypical cadherin 1

Explore in graph →CI-GENE-00001648HGNC:3595 ENSG00000083857 NCBI 2195 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FAT1 Loss1
CDK4/6 Inhibition	Malignant Breast Neoplasm	Predictive	B	Supports Resistance	3	submitted	EID12263 Drug resistance to CDK4/6 inhibitors was analyzed in a genomic study of 348 estrogen receptor-positive (ER+) breast cancer cases. Among patients treated with CDK4/6 inhibitors, those with FAT1 mutatio… (full text at CIViC) PMID 30537512 · Li et al., 2018 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (200)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved200 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Metastatic Biliary Tract Cancers (SUMMIT - Neratinib Basket Trial, 2022) biliary_tract_summit_2022	unmapped	Ssm	1	16	6.3%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.