Gene

ERG

ETS transcription factor ERG

Explore in graph →CI-GENE-00044932HGNC:3446 ENSG00000157554 NCBI 2078 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (9)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–9 of 9 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ERG Fusion3
(diagnostic)	Ewing Sarcoma	Diagnostic	B	Supports Positive	5	accepted	EID475 The t(21;22) rearrangement resulting in the EWSR1::ERG fusion is associated with the diagnosis of Ewing sarcoma. EWSR1::ERG is the second most common gene fusion reported in this disease.

Cohorts

Alteration frequency by cohort (65)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved65 cohort rows (showing 15, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Breast Cancer (MSK, Nat Genet 2025) breast_msk_2025	Invasive Breast Carcinoma	Ssm	30

Literature

Linked publications (7)

25 per page, newest first.

pubmedPublishedShowing 1–7 of 7 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Integrated multimodal genetic testing of Ewing sarcoma--a single-institution experience.
· Hum Pathol · 2013 · PMID 23706910 · validated civic_curation pubmed
Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.
· Blood · 1997 · PMID 9242552 · validated civic_curation pubmed
Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group.
· Blood · 2018 · PMID 30150206 · validated civic_curation pubmed
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.
· Science · 2005 · PMID 16254181 · validated civic_curation

ERG Fusion4
(diagnostic)	Acute Myeloid Leukemia with FUS-ERGALIAS	Diagnostic	B	Supports Positive	4	accepted	EID12321 This study investigates the diagnostic importance of the translocation t(16;21)(p11;q22), resulting in the TLS/FUS::ERG fusion gene, in acute myeloid leukemia (AML). The authors utilized RT-PCR to det… (full text at CIViC) PMID 9242552 · Kong et al., 1997 · Open in CIViC	civic
〃	Acute Myeloid Leukemia with FUS-ERGALIAS	Diagnostic	B	Supports Positive	4	accepted	EID12322 This international retrospective study investigates the diagnostic features of acute myeloid leukemia (AML) with the t(16;21) translocation resulting in the FUS::ERG fusion gene in pediatric patients.… (full text at CIViC) PMID 30150206 · Noort et al., 2018 · Open in CIViC	civic
〃	Ewing Sarcoma	Diagnostic	B	Supports Positive	3	submitted	EID11601 An analysis of 85 small blue round cell tumors (SBRCTs) that were negative for EWSR1, CIC, or BCOR by FISH identified 6 FUS::ERG and 1 FUS::FEV fusions. Clinicopathologic characterization of these 7 … (full text at CIViC) PMID 26690869 · Chen et al., 2016 · Open in CIViC	civic
〃	Acute Myeloid Leukemia with FUS-ERGALIAS	Diagnostic	C	Supports Positive	3	accepted	EID12323 This study focuses on the diagnostic characteristics of pediatric patients with the t(16;21)(p11;q22)/FUS::ERG translocation using advanced molecular methods. The authors studied four cases of pediatr… (full text at CIViC) PMID 29427188 · Zerkalenkova et al., 2018 · Open in CIViC	civic

ERG Fusion4

(diagnostic)

Acute Myeloid Leukemia with FUS-ERGALIAS

Diagnostic

Supports Positive

accepted

EID12321

This study investigates the diagnostic importance of the translocation t(16;21)(p11;q22), resulting in the TLS/FUS::ERG fusion gene, in acute myeloid leukemia (AML). The authors utilized RT-PCR to det… (full text at CIViC)

PMID 9242552 · Kong et al., 1997 · Open in CIViC

civic

〃

Acute Myeloid Leukemia with FUS-ERGALIAS

Diagnostic

Supports Positive

accepted

EID12322

This international retrospective study investigates the diagnostic features of acute myeloid leukemia (AML) with the t(16;21) translocation resulting in the FUS::ERG fusion gene in pediatric patients.… (full text at CIViC)

PMID 30150206 · Noort et al., 2018 · Open in CIViC

civic

〃

Ewing Sarcoma

Diagnostic

Supports Positive

submitted

EID11601

An analysis of 85 small blue round cell tumors (SBRCTs) that were negative for EWSR1, CIC, or BCOR by FISH identified 6 FUS::ERG and 1 FUS::FEV fusions. Clinicopathologic characterization of these 7 … (full text at CIViC)

PMID 26690869 · Chen et al., 2016 · Open in CIViC

civic

〃

Acute Myeloid Leukemia with FUS-ERGALIAS

Diagnostic

Supports Positive

accepted

EID12323

This study focuses on the diagnostic characteristics of pediatric patients with the t(16;21)(p11;q22)/FUS::ERG translocation using advanced molecular methods. The authors studied four cases of pediatr… (full text at CIViC)

PMID 29427188 · Zerkalenkova et al., 2018 · Open in CIViC

civic

CDKN2A Deletion + CDKN2B Deletion + ERG Deletion + IKZF1 Deletion + CRLF2 Fusion + PAX5 DeletionPAX5 CDKN2B ERG IKZF1 CRLF2 CDKN2A1
(prognostic)	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	5	submitted	EID7786 83 of 991 cases of pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) were found to have IKZF1 deletion, previously reported as an independent factor associated with a poor prognosis.… (full text at CIViC) PMID 29498923 · Stanulla et al., 2018 · Open in CIViC	civic

CDKN2A Deletion + CDKN2B Deletion + ERG Deletion + IKZF1 Deletion + CRLF2 Fusion + PAX5 DeletionPAX5 CDKN2B ERG IKZF1 CRLF2 CDKN2A1

(prognostic)

B Lymphoblastic Leukemia/LymphomaCURATED_BROADER

Prognostic

Supports Poor Outcome

submitted

EID7786

83 of 991 cases of pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) were found to have IKZF1 deletion, previously reported as an independent factor associated with a poor prognosis.… (full text at CIViC)

PMID 29498923 · Stanulla et al., 2018 · Open in CIViC

civic

ERG Fusion1
(diagnostic)	Prostate Carcinoma	Diagnostic	B	Supports Positive	3	accepted	EID476 TMPRSS2/ERG gene fusion was observed in 23 of 29 (79%) of prostate carcinoma samples, and 90% of ERG expression positive prostate carcinoma samples. PMID 16254181 · Tomlins et al., 2005 · Open in CIViC	civic

ERG Fusion1

(diagnostic)

Prostate Carcinoma

Diagnostic

Supports Positive

accepted

EID476

TMPRSS2/ERG gene fusion was observed in 23 of 29 (79%) of prostate carcinoma samples, and 90% of ERG expression positive prostate carcinoma samples.

PMID 16254181 · Tomlins et al., 2005 · Open in CIViC

civic