ERG Fusion

CI-VAR-00001385Explore in graph →CIViC 4602

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Ewing Sarcoma3
EWSR1::ERG Fusion	(diagnostic)	Diagnostic	B	Supports Positive	5	accepted	EID475 The t(21;22) rearrangement resulting in the EWSR1::ERG fusion is associated with the diagnosis of Ewing sarcoma. EWSR1::ERG is the second most common gene fusion reported in this disease. PMID 23706910 · Warren et al., 2013 · Open in CIViC	civic
EWSR1::ERG Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID10338 Molecular analysis of 30 Ewing tumors (designated as Ewing's sarcomas and primitive neuroectodermal tumors (PNET) in this 1994 paper) from patients with well-documented clinical course was performed. … (full text at CIViC) PMID 7524604 · Zoubek et al., 1994 · Open in CIViC	civic
EWSR1::ERG Fusion	(diagnostic)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.