DDIT3 — gene · CancerIndex

Gene

DDIT3

DNA damage inducible transcript 3

Explore in graph →CI-GENE-00043046HGNC:2726 ENSG00000175197 NCBI 1649 Cancer geneApproved

Curated evidence

Clinical evidence (8)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–8 of 8 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
DDIT3 Fusion3
(diagnostic)	Liposarcoma	Diagnostic	B	Supports Positive	3	submitted	EID7982 Both RT-PCR and PCR were used to detect and confirm the presence of fusion transcripts in RNA extracted from the surgical resections of 74 liposarcomas and 98 lipomas. EWSR1-DDIT3 (EWS-CHOP) was foun… (full text at CIViC) PMID 20332486 · Kubo et al., 2010 · Open in CIViC	civic
〃	Myxoid Liposarcoma	Diagnostic	C	Supports Positive	3	accepted	EID1778 Identified two cases of myxoid liposarcoma with translocations (between 12q13 and 22q12) giving rise to EWSR1-DDIT3 (EWS-CHOP) fusions instead of the more common FUS-DDIT3. PMID 8637704 · Panagopoulos et al., 1996 · Open in CIViC	civic
〃

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Adrenocortical Carcinoma TCGA-ACC	Adrenal Cortical CarcinomaALIAS

Literature

Linked publications (5)

25 per page, newest first.

pubmedPublishedShowing 1–5 of 5 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Specificity of fusion genes in adipocytic tumors.
· Anticancer Res · 2010 · PMID 20332486 · validated civic_curation pubmed
Fusion of the EWS and CHOP genes in myxoid liposarcoma.
· Oncogene · 1996 · PMID 8637704 · validated civic_curation pubmed
Cytogenetic findings in liposarcoma correlate with histopathologic subtypes.
· Cancer · 1992 · PMID 1568170 · validated civic_curation pubmed
The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice.
· Oncogene · 2000 · PMID 10828883 · validated civic_curation pubmed
FUS-DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma.

DDIT3 Fusion5
(diagnostic)	Liposarcoma	Diagnostic	B	Supports Positive	4	accepted	EID7981 Both RT-PCR and PCR were used to detect and confirm the presence of fusion transcripts in RNA extracted from the surgical resections of 74 liposarcomas and 98 lipomas. FUS-DDIT3 (TLS-CHOP) was found … (full text at CIViC) PMID 20332486 · Kubo et al., 2010 · Open in CIViC	civic
〃	Myxoid Liposarcoma	Diagnostic	C	Supports Positive	2	accepted	EID1785 In this 1992 paper, 9 of 26 liposarcoma patients had a histopathologic diagnosis of myxoid liposarcoma. Cytogenetic analysis revealed 6 of these patients had t(12;16)(q13;p11). 2 patients had a cyt… (full text at CIViC) PMID 1568170 · Sreekantaiah et al., 1992 · Open in CIViC	civic
〃	Myxoid Liposarcoma	Diagnostic	D	Supports Positive	4	accepted	EID12430 This study provided in vivo evidence showing the adipocyte-specific oncogenicity of the FUS::CHOP fusion transcript in liposarcoma, using a transgenic mouse model with ubiquitous FUS::CHOP expression … (full text at CIViC) PMID 10828883 · Pérez-Losada et al., 2000 · Open in CIViC	civic
〃	Myxoid Liposarcoma	Diagnostic	D	Supports Positive	2	accepted	EID12431 This preclinical study examined the effect of the FUS::DDIT3 fusion protein on the oncogenic role of IGF-1R/PI3K/Akt signaling in myxoid liposarcoma (MLS) and explored the therapeutic potential of IGF… (full text at CIViC) PMID 28637688 · Trautmann et al., 2017 · Open in CIViC	civic
NVP-AEW541	Myxoid Liposarcoma	Predictive	D	Supports Sensitivity Response	3	submitted	EID5920 A comprehensive subset of myxoid liposarcoma specimens showed elevated expression and phosphorylation levels of various IGF-IR/PI3K/Akt signaling effectors. In HT1080 fibrosarcoma cells, overexpressio… (full text at CIViC) PMID 28637688 · Trautmann et al., 2017 · Open in CIViC	civic