Publication
The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice.
Authors not recorded
Oncogene2000PMID 10828883stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerMyxoid Liposarcomacivic_curation1.00
- geneDDIT3civic_curation1.00
- variantDDIT3 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 10828883
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| DDIT3 Fusion1 | ||||||||
| (diagnostic) | Myxoid Liposarcoma | Diagnostic | D | Supports Positive | 4 | accepted | EID12430This study provided in vivo evidence showing the adipocyte-specific oncogenicity of the FUS::CHOP fusion transcript in liposarcoma, using a transgenic mouse model with ubiquitous FUS::CHOP expression … (full text at CIViC) PMID 10828883 · Pérez-Losada et al., 2000 · Open in CIViC | civic |