Myxoid Liposarcoma — Variants & evidence

Myxoid Liposarcoma — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

6 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–6 of 6 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CTAG1B Expression1
Letetresgene Autoleucel	Predictive	B	Supports Sensitivity Response	3	accepted	EID12573 In the phase II trial (NCT02992743) of letetresgene autoleucel (lete-cel) in human leukocyte antigen ((HLA)-A02:01–, HLA-A02:05–, and/or HLA-A*02:06–positive), NY-ESO-1 (CTAG1B)-expressing advanced … (full text at CIViC) PMID 39836945 · D'Angelo et al., 2025 · Open in CIViC	civic
DDIT3 Fusion1
(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID1778 Identified two cases of myxoid liposarcoma with translocations (between 12q13 and 22q12) giving rise to EWSR1-DDIT3 (EWS-CHOP) fusions instead of the more common FUS-DDIT3. PMID 8637704 · Panagopoulos et al., 1996 · Open in CIViC	civic
DDIT3 Fusion4
(diagnostic)	Diagnostic	C	Supports Positive	2	accepted	EID1785 In this 1992 paper, 9 of 26 liposarcoma patients had a histopathologic diagnosis of myxoid liposarcoma. Cytogenetic analysis revealed 6 of these patients had t(12;16)(q13;p11). 2 patients had a cyt… (full text at CIViC) PMID 1568170 · Sreekantaiah et al., 1992 · Open in CIViC	civic
〃	Diagnostic	D	Supports Positive	4	accepted	EID12430 This study provided in vivo evidence showing the adipocyte-specific oncogenicity of the FUS::CHOP fusion transcript in liposarcoma, using a transgenic mouse model with ubiquitous FUS::CHOP expression … (full text at CIViC) PMID 10828883 · Pérez-Losada et al., 2000 · Open in CIViC	civic
〃	Diagnostic	D	Supports Positive	2	accepted	EID12431 This preclinical study examined the effect of the FUS::DDIT3 fusion protein on the oncogenic role of IGF-1R/PI3K/Akt signaling in myxoid liposarcoma (MLS) and explored the therapeutic potential of IGF…

Data updated 13 minutes agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.