Publication
FUS-DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerMyxoid Liposarcomacivic_curation1.00
- geneDDIT3civic_curation1.00
- variantDDIT3 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28637688
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| DDIT3 Fusion2 | ||||||||
| (diagnostic) | Myxoid Liposarcoma | Diagnostic | D | Supports Positive | 2 | accepted | EID12431This preclinical study examined the effect of the FUS::DDIT3 fusion protein on the oncogenic role of IGF-1R/PI3K/Akt signaling in myxoid liposarcoma (MLS) and explored the therapeutic potential of IGF… (full text at CIViC) PMID 28637688 · Trautmann et al., 2017 · Open in CIViC | civic |
| NVP-AEW541 | Myxoid Liposarcoma | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID5920A comprehensive subset of myxoid liposarcoma specimens showed elevated expression and phosphorylation levels of various IGF-IR/PI3K/Akt signaling effectors. In HT1080 fibrosarcoma cells, overexpressio… (full text at CIViC) PMID 28637688 · Trautmann et al., 2017 · Open in CIViC | civic |