Gene
CTCF
CCCTC-binding factor
Explore in graph →CI-GENE-00042486HGNC:13723 ENSG00000102974 NCBI 10664 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (3)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28319062
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CTCF K365T1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | accepted | EID10179Three recurrent CTCF mutations found in endometrial carcinoma were expressed in Ishikawa cells and compared to expression of wild-type CTCF. The K365T mutation did not demonstrate altered localization… (full text at CIViC) PMID 28319062 · Marshall et al., 2017 · Open in CIViC | civic |
| CTCF P378L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | submitted | EID9173Three recurrent CTCF mutations found in endometrial carcinoma were expressed in Ishikawa cells and compared to expression of wild-type CTCF. CTCF P378L showed similar nuclear localization and protein … | |
Cohorts
Alteration frequency by cohort (137)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| MSK-IMPACT Heme Tumors (MSK, 2022) heme_msk_impact_2022 | unmapped | Ssm | 26 | 2,383 | 1.1% | 114 |
Literature
Linked publications (1)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
· Oncogene · 2017 · PMID 28319062 · validated civic_curation pubmed