Subtype
Malignant Neoplasm of Unknown Primary
CI-CAN-00001150CUPExplore in graph →
4,158 active trials54 approved drugs532 evidence items
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Subtype
CI-CAN-00001150CUPExplore in graph →
Genomics
199 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
499 cases with simple somatic mutation data · 501 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | FRG1BP | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 97 |
| 499 |
| 19.4% |
| cbioportal |
| 2 | TTN | Ssm | 63 | 499 | 12.6% | cbioportal |
| 3 | TP53 | Ssm | 61 | 499 | 12.2% | cbioportal |
| 4 | SPOP | Ssm | 57 | 499 | 11.4% | cbioportal |
| 5 | MUC16 | Ssm | 38 | 499 | 7.6% | cbioportal |
| 6 | MUC17 | Ssm | 33 | 499 | 6.6% | cbioportal |
| 7 | KMT2C | Ssm | 30 | 499 | 6% | cbioportal |
| 8 | KMT2D | Ssm | 29 | 499 | 5.8% | cbioportal |
| 9 | FOXA1 | Ssm | 28 | 499 | 5.6% | cbioportal |
| 11 | SYNE1 | Ssm | 27 | 499 | 5.4% | cbioportal |
| 10 | NBPF1 | Ssm | 27 | 499 | 5.4% | cbioportal |
| 12 | SPTA1 | Ssm | 26 | 499 | 5.2% | cbioportal |
| 13 | KRTAP4-11 | Ssm | 24 | 499 | 4.8% | cbioportal |
| 14 | LRP1B | Ssm | 24 | 499 | 4.8% | cbioportal |
| 15 | NBPF10 | Ssm | 23 | 499 | 4.6% | cbioportal |
| 16 | ATM | Ssm | 22 | 499 | 4.4% | cbioportal |
| 17 | CSMD3 | Ssm | 22 | 499 | 4.4% | cbioportal |
| 18 | ZAN | Ssm | 22 | 499 | 4.4% | cbioportal |
| 20 | MUC4 | Ssm | 21 | 499 | 4.2% | cbioportal |
| 19 | CHEK2 | Ssm | 21 | 499 | 4.2% | cbioportal |
| 22 | HMCN1 | Ssm | 19 | 499 | 3.8% | cbioportal |
| 23 | RYR1 | Ssm | 19 | 499 | 3.8% | cbioportal |
| 21 | FAT3 | Ssm | 19 | 499 | 3.8% | cbioportal |
| 24 | CACNA1E | Ssm | 18 | 499 | 3.6% | cbioportal |
| 27 | USH2A | Ssm | 18 | 499 | 3.6% | cbioportal |
| 25 | OBSCN | Ssm | 18 | 499 | 3.6% | cbioportal |
| 26 | RGPD8 | Ssm | 18 | 499 | 3.6% | cbioportal |
| 29 | PTEN | Ssm | 17 | 499 | 3.4% | cbioportal |
| 30 | RYR2 | Ssm | 17 | 499 | 3.4% | cbioportal |
| 28 | MACF1 | Ssm | 17 | 499 | 3.4% | cbioportal |
Data updated 22 days agoSource updated 2026-01-16