Subtype
Malignant Neoplasm of Unknown Primary
CI-CAN-00001150CUPExplore in graph →
4,158 active trials54 approved drugs532 evidence items
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Subtype
CI-CAN-00001150CUPExplore in graph →
Genomics
199 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
61 cases with simple somatic mutation data · 121 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 25 |
| 61 |
| 41% |
| cbioportal |
| 2 | TTN | Ssm | 8 | 61 | 13.1% | cbioportal |
| 3 | ZFHX3 | Ssm | 8 | 61 | 13.1% | cbioportal |
| 5 | RYR3 | Ssm | 7 | 61 | 11.5% | cbioportal |
| 4 | ABCA13 | Ssm | 7 | 61 | 11.5% | cbioportal |
| 7 | DNAH11 | Ssm | 6 | 61 | 9.8% | cbioportal |
| 11 | RB1 | Ssm | 6 | 61 | 9.8% | cbioportal |
| 10 | PTEN | Ssm | 6 | 61 | 9.8% | cbioportal |
| 9 | MUC16 | Ssm | 6 | 61 | 9.8% | cbioportal |
| 8 | KMT2D | Ssm | 6 | 61 | 9.8% | cbioportal |
| 6 | APC | Ssm | 6 | 61 | 9.8% | cbioportal |
| 14 | USH2A | Ssm | 5 | 61 | 8.2% | cbioportal |
| 12 | AR | Ssm | 5 | 61 | 8.2% | cbioportal |
| 13 | CSMD1 | Ssm | 5 | 61 | 8.2% | cbioportal |
| 31 | SCN5A | Ssm | 4 | 61 | 6.6% | cbioportal |
| 19 | DGKB | Ssm | 4 | 61 | 6.6% | cbioportal |
| 30 | RYR1 | Ssm | 4 | 61 | 6.6% | cbioportal |
| 21 | FREM2 | Ssm | 4 | 61 | 6.6% | cbioportal |
| 20 | FAT4 | Ssm | 4 | 61 | 6.6% | cbioportal |
| 29 | PLEC | Ssm | 4 | 61 | 6.6% | cbioportal |
| 28 | NEB | Ssm | 4 | 61 | 6.6% | cbioportal |
| 27 | NAALADL2 | Ssm | 4 | 61 | 6.6% | cbioportal |
| 15 | ASXL2 | Ssm | 4 | 61 | 6.6% | cbioportal |
| 26 | MAGI3 | Ssm | 4 | 61 | 6.6% | cbioportal |
| 25 | LPAR1 | Ssm | 4 | 61 | 6.6% | cbioportal |
| 35 | VCAN | Ssm | 4 | 61 | 6.6% | cbioportal |
| 24 | JARID2 | Ssm | 4 | 61 | 6.6% | cbioportal |
| 16 | ATM | Ssm | 4 | 61 | 6.6% | cbioportal |
| 23 | HSPG2 | Ssm | 4 | 61 | 6.6% | cbioportal |
| 36 | ZFHX4 | Ssm | 4 | 61 | 6.6% | cbioportal |
Data updated 22 days agoSource updated 2026-01-13