Cancer Family
Malignant Head and Neck Neoplasm
CI-CAN-00000236Explore in graph →
1,432 active trials17 approved drugs142 evidence items
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Cancer Family
CI-CAN-00000236Explore in graph →
Clinical trials
5,449 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (629)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT05581550 | Somatostatin Receptor Imaging in NPC, EBV Related Cancers | completed | N/A | 15 | National Cancer Centre, SingaporeOTHER | 1 | Jul 20, 2025 | clinicaltrials |
| NCT02358031 | A Study of Pembrolizumab (MK-3475) for First Line Treatment of Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck (MK-3475-048/KEYNOTE-048) | completed | Phase 3 | 882 | Merck Sharp & Dohme LLCINDUSTRY | 0 | Jul 18, 2025 | clinicaltrials |
| NCT07066644 | Intraoperative Pathologic Evaluation of Central Lymph Nodes in Papillary Thyroid Carcinoma | completed | — | 509 | Seoul National University HospitalOTHER | 1 | Jul 18, 2025 | clinicaltrials |
| NCT03984357 | Nivolumab Combined With Chemoradiotherapy Sparing Concurrent Cisplatin in Nasopharyngeal Carcinoma(PLATINUM) | completed | Phase 2 | 152 | Sun Yat-sen UniversityOTHER | 1 | Jul 17, 2025 | clinicaltrials |
| NCT04247282 | Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection | completed | Phase 1 / Phase 2 | 21 | National Cancer Institute (NCI)NIH | 1 | Jul 16, 2025 | clinicaltrials |
| NCT04242199 | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors | completed | Phase 1 | 182 | Incyte CorporationINDUSTRY | 5 | Jul 14, 2025 | clinicaltrials |
| NCT04580485 | INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors | completed | Phase 1 | 54 | Incyte CorporationINDUSTRY | 6 | Jul 11, 2025 | clinicaltrials |
| NCT04330781 | Radiotherapy of Head and Neck Cancer Using an Intraoral Stent | completed | Phase 2 | 220 | Oslo University HospitalOTHER | 1 | Jul 9, 2025 | clinicaltrials |
| NCT04833257 | Neoadjuvant Therapy of GP Chemotherapy Combined With Tislelizumab in Locoregionally Advanced NPC | completed | Phase 2 | 63 | Sun Yat-sen UniversityOTHER | 1 | Jul 8, 2025 | clinicaltrials |
| NCT00832429 | Lymph Node Mapping in Finding Metastatic Disease in Patients With Sebaceous Gland Cancer of the Eyelid | completed | Phase 2 | 20 | M.D. Anderson Cancer CenterOTHER | 1 | Jul 4, 2025 | clinicaltrials |
| NCT03635164 | Radiotherapy With Durvalumab Prior to Surgical Resection for HPV Negative Squamous Cell Carcinoma | completed | Phase 1 | 21 | University of Colorado, DenverOTHER | 1 | Jun 27, 2025 | clinicaltrials |
| NCT06112535 | Prospective Clinical Study to Assess the Safety and Efficacy of Versius, in Transoral Robotic Surgery | completed | N/A | 60 | CMR Surgical LtdINDUSTRY | 1 | Jun 25, 2025 | clinicaltrials |
| NCT05534594 | Evaluation of the 18F-PSMA Positron Emission Tomography (PET)/CT in Patients With Medullary Thyroid Cancer(MIMETIC) | completed | N/A | 8 | University Medical Center GroningenOTHER | 1 | Jun 24, 2025 | clinicaltrials |
| NCT03246958 | Nivolumab Plus Ipilimumab in Thyroid Cancer | completed | Phase 2 | 53 | Dana-Farber Cancer InstituteOTHER | 1 | Jun 19, 2025 | clinicaltrials |
| NCT04400474 | Trial of Cabozantinib Plus Atezolizumab in Advanced and Progressive Neoplasms of the Endocrine System. The CABATEN Study(CABATEN) | completed | Phase 2 | 93 | Grupo Espanol de Tumores NeuroendocrinosOTHER | 1 | Jun 19, 2025 | clinicaltrials |
| NCT04489888 | A Study of Pembrolizumab (MK-3475) Plus Carboplatin and Paclitaxel as First-line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (MK-3475-B10/KEYNOTE B10) | completed | Phase 4 | 101 | Merck Sharp & Dohme LLCINDUSTRY | 5 | Jun 19, 2025 | clinicaltrials |
| NCT02145143 | Enhancing Radioiodine (RAI) Incorporation Into BRAF Mutant, RAI-Refractory Thyroid Cancers With the BRAF Inhibitor Vemurafenib: A Pilot Study | completed | Early Phase 1 | 12 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Jun 18, 2025 | clinicaltrials |
| NCT03114163 | Observational Study of Nivolumab in Participants in Germany With Squamous Cell Carcinoma of the Head and Neck (SCCHN) Progressing on or After Platinum-Based Therapy | completed | — | 485 | Bristol-Myers SquibbINDUSTRY | 1 | Jun 18, 2025 | clinicaltrials |
| NCT05788484 | A Study of CDX-585 in Patients With Advanced Malignancies | completed | Phase 1 | 20 | Celldex TherapeuticsINDUSTRY | 1 | Jun 15, 2025 | clinicaltrials |
| NCT05253053 | To Evaluate Efficacy and Safety of TT-00420 (Tinengotinib) as Monotherapy and Combination Therapy in Patients With Advanced Solid Tumors | completed | Phase 1 / Phase 2 | 84 | TransThera Sciences (Nanjing), Inc.INDUSTRY | 1 | Jun 12, 2025 | clinicaltrials |
| NCT07015333 | Case Review of Patients With Betel Nut-induced Oral Cancer Treated With Pembrolizumab and Cetuximab | completed | — | 31 | Commonwealth Healthcare CorporationOTHER | 1 | Jun 11, 2025 | clinicaltrials |
| NCT04823468 | Effect of Oral Nutritional Supplements on Body Weight Loss of Patients With Nasopharyngeal Carcinoma | completed | N/A | 236 | Jinsheng HongOTHER | 1 | Jun 10, 2025 | clinicaltrials |
| NCT04616196 | Study of NKTR 255 in Combination With Cetuximab in Solid Tumors | completed | Phase 1 / Phase 2 | 25 | Nektar TherapeuticsINDUSTRY | 1 | Jun 8, 2025 | clinicaltrials |
| NCT07005115 | Serum Lipid Profile and Lip Squamous Cell Carcinoma | completed | — | 56 | Akdeniz UniversityOTHER | 1 | Jun 6, 2025 | clinicaltrials |
| NCT04552769 | Abemaciclib in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer | completed | Phase 2 | 9 | Stanford UniversityOTHER | 1 | Jun 5, 2025 | clinicaltrials |
| NCT02792322 | Robotic Surgery in the Seated Position for Benign and Malignant Lesions of the Head and Neck | completed | N/A | 32 | Mayo ClinicOTHER | 1 | Jun 4, 2025 | clinicaltrials |
| NCT06325514 | Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis | completed | — | 241 | Cairo UniversityOTHER | 1 | Jun 4, 2025 | clinicaltrials |
| NCT03317327 | REirradiation and Programmed Cell Death Protein 1 (PD-1) Blockade On Recurrent Squamous Cell Head and Neck Tumors(REPORT) | completed | Phase 1 / Phase 2 | 20 | Oslo University HospitalOTHER | 1 | Jun 3, 2025 | clinicaltrials |
| NCT02331134 | Tissue and Hematopoietic/Mesenchymal Stem Cell for Humanized Xenograft Studies in Melanoma and Squamous Head and Neck Cancer | completed | N/A | 9 | University of Colorado, DenverOTHER | 1 | May 31, 2025 | clinicaltrials |
| NCT03037385 | Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors(ARROW) | completed | Phase 1 / Phase 2 | 590 | Hoffmann-La RocheINDUSTRY | 13 | May 31, 2025 | clinicaltrials |
| NCT05499065 | Real-time Margin Assessment in Head and Neck Cancer(LIGHTNING) | completed | Phase 2 | 23 | University Medical Center GroningenOTHER | 1 | May 31, 2025 | clinicaltrials |
| NCT06991309 | Mindfulness-based Stress Reduction Effects on Depression, Anxiety and Internalized Stigma Compared With Treatment-As-Usual Among Head and Neck Cancer Patients | completed | N/A | 110 | Universiti Sains MalaysiaOTHER | 1 | May 31, 2025 | clinicaltrials |
| NCT06757530 | Radiomics Model for Assessing Lymph Node Status in cN0 Patients withHNSCC | completed | — | 700 | First Affiliated Hospital of Chongqing Medical UniversityOTHER | 1 | May 28, 2025 | clinicaltrials |
| NCT02147418 | Exosome Testing as a Screening Modality for Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma | completed | — | 15 | New Mexico Cancer Research AllianceOTHER | 1 | May 22, 2025 | clinicaltrials |
| NCT03548285 | Stereotactic Ablative Radiotherapy for Early-stage Glottic Larynx Cancer | completed | N/A | 25 | University of Texas Southwestern Medical CenterOTHER | 1 | May 22, 2025 | clinicaltrials |
| NCT03953443 | Expression & Epigenetic Silencing of MicroRNA for Predicting Therapeutic Response and Prognosis of HPV-negative HNSCC | completed | — | 25 | New Mexico Cancer Research AllianceOTHER | 1 | May 22, 2025 | clinicaltrials |
| NCT04788264 | Exercise Training and Behavioral Modification for the Improvement of Physical Activity in Head and Neck Cancer Patients Undergoing Cancer Treatment | completed | N/A | 12 | Thomas Jefferson UniversityOTHER | 1 | May 22, 2025 | clinicaltrials |
| NCT05516589 | Neoadjuvant Chemotherapy, Tislelizumab With Afatinib for HNSCC(neoCHANCE-2) | completed | Phase 2 | 40 | West China HospitalOTHER | 1 | May 22, 2025 | clinicaltrials |
| NCT02555176 | Low-Carbohydrate Normocaloric Diet in Patients With Head and Neck Carcinoma (HNC) | completed | N/A | 7 | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson UniversityOTHER | 1 | May 20, 2025 | clinicaltrials |
| NCT04121286 | A Study of JAB-3312 in Adult Patients With Advanced Solid Tumors in China | completed | Phase 1 | 17 | Allist Pharmaceuticals, Inc.INDUSTRY | 1 | May 20, 2025 | clinicaltrials |
| NCT04129411 | Treatment of Papillary Thyroid Carcinoma With Radiofrequency Ablation | completed | N/A | 5 | Mayo ClinicOTHER | 1 | May 20, 2025 | clinicaltrials |
| NCT04555837 | Alisertib and Pembrolizumab for the Treatment of Patients With Rb-deficient Head and Neck Squamous Cell Cancer | completed | Phase 1 / Phase 2 | 24 | M.D. Anderson Cancer CenterOTHER | 1 | May 20, 2025 | clinicaltrials |
| NCT03274414 | A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages | completed | Phase 2 | 3 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | May 16, 2025 | clinicaltrials |
| NCT02245100 | Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer | completed | — | 130 | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson UniversityOTHER | 1 | May 15, 2025 | clinicaltrials |
| NCT02318771 | Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer | completed | Phase 1 | 41 | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson UniversityOTHER | 1 | May 15, 2025 | clinicaltrials |
| NCT03618654 | Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma | completed | Early Phase 1 | 38 | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson UniversityOTHER | 1 | May 15, 2025 | clinicaltrials |
| NCT04666428 | Effects of Human Papillomavirus Diagnosis on Relationships of Patients With Head and Neck Cancer | completed | — | 30 | Thomas Jefferson UniversityOTHER | 1 | May 15, 2025 | clinicaltrials |
| NCT06969768 | Proteogenomics for Follicular Cell-derived Thyroid Cancer: Development of a Classification and Prognosis Prediction Model | completed | — | 275 | Seoul National University HospitalOTHER | 1 | May 14, 2025 | clinicaltrials |
| NCT03524326 | Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma | completed | Phase 1 | 24 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | May 13, 2025 | clinicaltrials |
| NCT03944915 | De-Escalation Therapy for Human Papillomavirus Negative Disease(DEPEND) | completed | Phase 2 | 35 | University of ChicagoOTHER | 1 | May 11, 2025 | clinicaltrials |
Data updated 23 days agoSource updated Jul 20, 2025source: clinicaltrials