Clinical trial · Interventional
Treatment of Papillary Thyroid Carcinoma With Radiofrequency Ablation
Pilot Study for the Treatment of Papillary Thyroid Carcinoma With Radiofrequency Ablation
NCT04129411CI-TRIAL-00089961completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Investigators intend to evaluate the efficiency of Radiofrequency ablation (RFA) therapy to treat papillary thyroid carcinoma.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Papillary Thyroid Cancer | Thyroid Gland Papillary Carcinoma | ALIAS | 0.90 |
| Papillary Thyroid Microcarcinoma | Thyroid Gland Papillary Microcarcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| RFA | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- RFA Group
- interventionNames
- Device: RFA
Primary outcomes (1)
- measure
- Changes in Thyroid Nodule Size
- timeFrame
- 24 months
- description
- Thyroid tumor volume shrinkage will be assessed by ultrasound and compared with pre-procedure volume (measure in mL)
Secondary outcomes (5)
- measure
- Pain Related to RFA Procedure
- timeFrame
- Up to 24 months
- description
- Assessed by number of participants that reported any pain related to RFA procedure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Are adults * Nodule with Papillary thyroid carcinoma meeting the below criteria: * Diagnosed by fine needle aspiration (FNA) cytology. * Size \< 1.5 cm * Non-surgical therapy is considered acceptable by the treating physician * Radiology evaluation deems the lesion amenable to RFA therapy with minimal risk of complication Exclusion Criteria: * Clinical evidence for a multifocal papillary thyroid malignancy * Clinical evidence for local or distant metastatic disease * Pregnancy * Vocal cord paralysis on contralateral side * Coagulopathy or patients on anticoagulation therapy * Patients with prior neck surgery or neck radiation * Patients with neck anatomy that precludes easy access by RFA * Patients with comorbidities deemed too high of a risk for general anesthesia * Treatment with another investigational drug or intervention (within 6 weeks of planned RFA). * Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
References
Publications (0)
Data not yet available
No reference posted for this study.