Clinical trial · Observational
Serum Lipid Profile and Lip Squamous Cell Carcinoma
Analysis of Serum Lipid Profile in Patients With Lip Squamous Cell Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational retrospective study is to assess whether serum lipid levels differ between patients diagnosed with lip squamous cell carcinoma (SCC) and healthy individuals. The study aims to evaluate if alterations in lipid parameters, especially LDL levels, are associated with the presence of lip SCC and could serve as potential early biomarkers. The main research questions are: Do patients with lip SCC show significantly lower LDL levels compared to healthy controls? Are there significant differences in total cholesterol (TC), triglycerides (TG), HDL, and VLDL between the two groups? A retrospective analysis was conducted using existing medical records of patients with lip SCC and healthy subjects obtained from 2018-2023.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lip Cancer | Malignant Lip Neoplasm | ALIAS | 0.90 |
| Lipid Profile | — | UNRESOLVED | — |
| Lipids | — | UNRESOLVED | — |
| Oral Cancer | Malignant Lip and Oral Cavity Neoplasm | CURATED_BROADER | 0.80 |
| SCC - Squamous Cell Carcinoma | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- study group
- description
- patients clinically evident and histopathologically confirmed with lip SCC
- label
- control group
- description
- subjects without any underlying systemic disease
Primary outcomes (1)
- measure
- Low-Density Lipoprotein (LDL) Levels in Patients With Lip SCC vs. Healthy Controls
- timeFrame
- At time of diagnosis (retrospective data collection)
- description
- To assess whether there is a statistically significant difference in fasting serum LDL levels between patients diagnosed with lip squamous cell carcinoma (SCC) and healthy subjects.
Secondary outcomes (4)
- measure
- Total Cholesterol (TC) Levels in Patients With Lip SCC vs. Healthy Controls
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients clinically evident and histopathologically confirmed with lip SCC (study group) * subjects without any underlying systemic disease (control group) Exclusion Criteria: * Age younger than 18 years * pregnancy * smoking * history of radiotherapy or chemotherapy * family history of hyperlipidemia * accompanying malignancies other than lip SCC for both study and control groups
References
Publications (15)
- BACKGROUNDLohe VK, Degwekar SS, Bhowate RR, Kadu RP, Dangore SB. Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse. J Oral Pathol Med. 2010 Feb;39(2):141-8. doi: 10.1111/j.1600-0714.2009.00828.x. Epub 2009 Dec 7. PMID 20002982
- BACKGROUNDKark JD, Smith AH, Hames CG. Serum retinol and the inverse relationship between serum cholesterol and cancer. Br Med J (Clin Res Ed). 1982 Jan 16;284(6310):152-4. doi: 10.1136/bmj.284.6310.152. PMID 6799076
- BACKGROUNDMehta R, Gurudath S, Dayansoor S, Pai A, Ganapathy KS. Serum lipid profile in patients with oral cancer and oral precancerous conditions. Dent Res J (Isfahan). 2014 May;11(3):345-50. doi: 10.4103/1735-3327.135889. PMID 25097644
- BACKGROUNDKumar P, Augustine J, Urs AB, Arora S, Gupta S, Mohanty VR. Serum lipid profile in oral cancer and leukoplakia: correlation with tobacco abuse and histological grading. J Cancer Res Ther. 2012 Jul-Sep;8(3):384-8. doi: 10.4103/0973-1482.103517. PMID 23174719
- BACKGROUNDGerber M, Richardson S, Crastes de Paulet P, Pujol H, Crastes de Paulet A. Relationship between vitamin E and polyunsaturated fatty acids in breast cancer. Nutritional and metabolic aspects. Cancer. 1989 Dec 1;64(11):2347-53. doi: 10.1002/1097-0142(19891201)64:113.0.co;2-v. PMID 2804926
- BACKGROUNDForones NM, Falcao JB, Mattos D, Barone B. Cholesterolemia in colorectal cancer. Hepatogastroenterology. 1998 Sep-Oct;45(23):1531-4. PMID 9840100
- BACKGROUNDNeville BW, Day TA. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002 Jul-Aug;52(4):195-215. doi: 10.3322/canjclin.52.4.195. PMID 12139232
- Patel PS, Shah MH, Jha FP, Raval GN, Rawal RM, Patel MM, Patel JB, Patel DD. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J Cancer. 2004 Jan-Mar;41(1):25-31.