Cancer Family
Malignant Head and Neck Neoplasm
CI-CAN-00000236Explore in graph →
1,431 active trials17 approved drugs142 evidence items
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Cancer Family
CI-CAN-00000236Explore in graph →
Genomics
26 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
1,049 cases with simple somatic mutation data · 1,049 cases total · 2026-01-05 · mapped to Adenoid Cystic Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | NOTCH1 | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 232 |
| 1,049 |
| 22.1% |
| cbioportal |
| 2 | KDM6A | Ssm | 138 | 1,049 | 13.2% | cbioportal |
| 3 | ARID1A | Ssm | 120 | 1,049 | 11.4% | cbioportal |
| 4 | KMT2D | Ssm | 111 | 1,049 | 10.6% | cbioportal |
| 5 | BCOR | Ssm | 109 | 1,049 | 10.4% | cbioportal |
| 6 | KMT2C | Ssm | 99 | 1,049 | 9.4% | cbioportal |
| 7 | CREBBP | Ssm | 98 | 1,049 | 9.3% | cbioportal |
| 9 | TERT | Ssm | 82 | 1,049 | 7.8% | cbioportal |
| 8 | ARID1B | Ssm | 82 | 1,049 | 7.8% | cbioportal |
| 10 | TP53 | Ssm | 76 | 1,049 | 7.2% | cbioportal |
| 11 | EP300 | Ssm | 74 | 1,049 | 7.1% | cbioportal |
| 12 | RUNX1 | Ssm | 71 | 1,049 | 6.8% | cbioportal |
| 13 | SPEN | Ssm | 67 | 1,049 | 6.4% | cbioportal |
| 14 | BRCA2 | Ssm | 64 | 1,049 | 6.1% | cbioportal |
| 15 | ATM | Ssm | 59 | 1,049 | 5.6% | cbioportal |
| 16 | FAT1 | Ssm | 57 | 1,049 | 5.4% | cbioportal |
| 17 | PIK3CA | Ssm | 54 | 1,049 | 5.1% | cbioportal |
| 18 | LRP1B | Ssm | 52 | 1,049 | 5% | cbioportal |
| 19 | PIK3R1 | Ssm | 49 | 1,049 | 4.7% | cbioportal |
| 21 | NOTCH3 | Ssm | 44 | 1,049 | 4.2% | cbioportal |
| 20 | MED12 | Ssm | 44 | 1,049 | 4.2% | cbioportal |
| 23 | TSC2 | Ssm | 43 | 1,049 | 4.1% | cbioportal |
| 22 | IRS2 | Ssm | 43 | 1,049 | 4.1% | cbioportal |
| 24 | FAT3 | Ssm | 41 | 1,049 | 3.9% | cbioportal |
| 25 | NTRK1 | Ssm | 40 | 1,049 | 3.8% | cbioportal |
| 27 | SPTA1 | Ssm | 36 | 1,049 | 3.4% | cbioportal |
| 26 | NOTCH2 | Ssm | 36 | 1,049 | 3.4% | cbioportal |
| 28 | PARP4 | Ssm | 35 | 1,049 | 3.3% | cbioportal |
| 29 | FBXW7 | Ssm | 33 | 1,049 | 3.1% | cbioportal |
| 30 | AR | Ssm | 32 | 1,049 | 3.1% | cbioportal |
Data updated 22 days agoSource updated 2026-01-05