Subtype
Malignant Colorectal Neoplasm
CI-CAN-00005874Explore in graph →
1,565 active trials21 approved drugs382 evidence items
- NCIt
- C4978
- DOID
- 9256
- Other
- 1 more code
Loading cancer entity…
Subtype
CI-CAN-00005874Explore in graph →
Genomics
27 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
339 cases with simple somatic mutation data · 339 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 268 |
| 339 |
| 79.1% |
| cbioportal |
| 2 | APC | Ssm | 257 | 339 | 75.8% | cbioportal |
| 3 | KRAS | Ssm | 152 | 339 | 44.8% | cbioportal |
| 4 | FBXW7 | Ssm | 66 | 339 | 19.5% | cbioportal |
| 5 | SMAD4 | Ssm | 47 | 339 | 13.9% | cbioportal |
| 130 | CYLD | Ssm | 5 | 49 | 10.2% | cbioportal |
| 6 | PIK3CA | Ssm | 33 | 339 | 9.7% | cbioportal |
| 8 | TCF7L2 | Ssm | 28 | 300 | 9.3% | cbioportal |
| 7 | ARID1A | Ssm | 28 | 339 | 8.3% | cbioportal |
| 181 | KMT2B | Ssm | 4 | 49 | 8.2% | cbioportal |
| 200 | UPF1 | Ssm | 4 | 49 | 8.2% | cbioportal |
| 192 | PREX2 | Ssm | 4 | 49 | 8.2% | cbioportal |
| 196 | SESN3 | Ssm | 4 | 49 | 8.2% | cbioportal |
| 199 | TP53BP1 | Ssm | 4 | 49 | 8.2% | cbioportal |
| 9 | SOX9 | Ssm | 21 | 339 | 6.2% | cbioportal |
| 11 | NOTCH3 | Ssm | 20 | 339 | 5.9% | cbioportal |
| 10 | ERBB3 | Ssm | 20 | 339 | 5.9% | cbioportal |
| 19 | MGA | Ssm | 17 | 300 | 5.7% | cbioportal |
| 13 | ATM | Ssm | 19 | 339 | 5.6% | cbioportal |
| 14 | KMT2C | Ssm | 19 | 339 | 5.6% | cbioportal |
| 12 | AMER1 | Ssm | 19 | 339 | 5.6% | cbioportal |
| 15 | PTPRS | Ssm | 19 | 339 | 5.6% | cbioportal |
| 17 | PTPRT | Ssm | 18 | 339 | 5.3% | cbioportal |
| 16 | BRAF | Ssm | 18 | 339 | 5.3% | cbioportal |
| 18 | AR | Ssm | 17 | 339 | 5% | cbioportal |
| 22 | ANKRD11 | Ssm | 15 | 300 | 5% | cbioportal |
| 21 | KMT2A | Ssm | 16 | 339 | 4.7% | cbioportal |
| 20 | EPHA5 | Ssm | 16 | 339 | 4.7% | cbioportal |
| 25 | SPEN | Ssm | 15 | 339 | 4.4% | cbioportal |
| 24 | NRAS | Ssm | 15 | 339 | 4.4% | cbioportal |
Data updated 22 days agoSource updated 2026-01-16