Molecular Subtype
Large B-Cell Lymphoma with IRF4 Rearrangement
CI-CAN-00005706Explore in graph →
Hematologic3 active trials3 evidence items
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Molecular Subtype
CI-CAN-00005706Explore in graph →
Data completeness3 / 7 dimensions
Computed from entity_counters.completeness · refreshed after each connector run
Definition
A large B-cell lymphoma that usually affects the Waldeyer ring and/or cervical lymph nodes and less often the gastrointestinal tract. It occurs most commonly in children and young adults and is low stage. It is characterized by a follicular, follicular and diffuse, or pure diffuse growth pattern resembling follicular lymphoma grade 3B or a diffuse large B-cell lymphoma. Most cases have IG/IRF4 rearrangements. BCL2 rearrangements are not present. Some cases that belong in this category lack an IRF4 rearrangement but have strong IRF4/MUM1 expression. This lymphoma is more aggressive than pediatric-type follicular lymphomas.
Data updated 22 days agoSource updated 26.08e
Taxonomy
Several hierarchies coexist; edges are listed per hierarchy type with their source.
Parents
Anatomy
Data updated 19 minutes agoSource updated unknowncounters aggregate over descendants
Names
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Key figures
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Data updated 19 minutes agoSource updated unknownregistry figures: cdc-uscs · latest year available per metric · counters aggregate over descendants