Digestive System Neoplasm

In a phase III study including 1183 colorectal cancer patients, panitumumab-FOLFOX4 significantly improved progression free survival (PFS) compared with FOLFOX4 (median PFS, 9.6 vs 8.0 months; HR = 0.… (full text at CIViC)

PMID 20921465 · Douillard et al., 2010 · Open in CIViC

In an in vitro study, a human colon adenocarcinoma SW48 cell line expressing KRAS wildtype did not demonstrate resistance to regorafenib treatment (IC50: 114.28 nM) compared to SW48 cells expressing v… (full text at CIViC)

PMID 26161928 · Camaj et al., 2015 · Open in CIViC

In a multinational cohort study of metastatic colorectal cancer (CRC), a novel LANCL2::EGFR fusion was detected by comprehensive NGS assay in one EGFR amplified (250 copies), RAS/BRAF wildtype CRC sam… (full text at CIViC)

PMID 33825902 · Randon et al., 2021 · Open in CIViC

Transfected cells with LGR5detla5-8 show significant decreased survival rate in comparison with transfected cells with LGR5FL (p< 0.05). Moreover addition of Anti-LGR5 exon 5 Ab shows significant decr… (full text at CIViC)

PMID 27140312 · Osawa et al., 2016 · Open in CIViC

FISH of the tumor and patient derived xenograft of a 75-year-old with metastatic colorectal cancer that spread to the liver indicated NTRK1 involvement. 5’RACE PCR discovered a novel LMNA-NTRK1 fusion… (full text at CIViC)

PMID 26563355 · Sartore-Bianchi et al., 2016 · Open in CIViC

After disease progression with no objective response to therapy, a 75-year-old with metastatic colorectal cancer that spread to the liver displayed elevated NTRK1 expression in both primary tumor and … (full text at CIViC)

PMID 26563355 · Sartore-Bianchi et al., 2016 · Open in CIViC

A gene fusion between exon 10 of NTRK1 and exon 11 of the LMNA genes was observed in a patient with metastatic colorectal cancer after therapy with first-line FOLFOX, second-line FOLFIRI/cetuximab, an… (full text at CIViC)

PMID 26546295 · Russo et al., 2016 · Open in CIViC

10 biliary tract carcinoma cell lines were sorted based on their gemcitabine sensitivity. MAGEH1 protein expression was negatively correlated with sensitivity. In a clinical validation cohort, MAGEH p… (full text at CIViC)

PMID 20088962 · Ojima et al., 2010 · Open in CIViC

This study identified a recurrent MALAT1::GLI1 fusion in 4 of 4 (100%) gastroblastomas from patients ranging in age from 9 to 56 years old. Initially, the fusion was identified using transcriptome seq… (full text at CIViC)

PMID 37165307 · Hamada et al., 2023 · Open in CIViC

In this 2017 study the authors included four cases of gastroblastoma with control cases of histologic mimics. Gastroblastoma patients were aged 9, 27, 28 and 56 years. RNASeq identified a MALAT1::GLI1… (full text at CIViC)

PMID 28731043 · Graham et al., 2017 · Open in CIViC

Paired pre-treatment and post-progression tumor biopsies from BRAF-mutant CRC patients treated with RAF inhibitor combinations were analyzed. Alterations in MAPK pathway genes were found in resistant … (full text at CIViC)

PMID 25673644 · Ahronian et al., 2015 · Open in CIViC

In a molecular case report, a MEK1 K57T mutation was found causing acquired resistancer to cetuximab.

PMID 26644315 · Russo et al., 2016 · Open in CIViC

Patients with metastatic colorectal cancer harboring BRAF V601E mutation were treated with binimetinib and panitumumab combination. Gene profiling at progressed tumor revealed MEK1 V211D mutation. V21… (full text at CIViC)

PMID 31227518 · Gao et al., 2019 · Open in CIViC

Patients with metastatic colorectal cancer harboring BRAF V601E mutation were treated with binimetinib and panitumumab combination. Gene profiling at progressed tumor revealed MEK1 V211D mutation. V21… (full text at CIViC)

PMID 31227518 · Gao et al., 2019 · Open in CIViC

In this case report, a 66-year old woman with pancreatic ductal adenocarcinoma was treated with trametinib for a BRAF in-frame-deletion and TP53 mutation and achieved an initial partial response for c… (full text at CIViC)

PMID 29903880 · Aguirre et al., 2018 · Open in CIViC

In this case report, a 66-year old woman with pancreatic ductal adenocarcinoma was treated with trametinib for a BRAF in-frame-deletion and TP53 mutation and achieved an initial partial response for c… (full text at CIViC)

PMID 29903880 · Aguirre et al., 2018 · Open in CIViC

In this case report, a 66-year old woman with pancreatic ductal adenocarcinoma was treated with trametinib for a BRAF in-frame-deletion and TP53 mutation and achieved an initial partial response for c… (full text at CIViC)

PMID 29903880 · Aguirre et al., 2018 · Open in CIViC

124 esophageal squamous cell carcinoma patients with radical resection were genotyped using MassArray. Patients with the DEL/A +AA genotype of MDM2 rs34886328 had a notably increased overall survival… (full text at CIViC)

PMID 27414035 · Li et al., 2016 · Open in CIViC

A total of 185 patients with stage III or IV esophageal + junctional cancers were tested for amplified genes in this retrospective study. There were 5 MET amplifications, 14 EGFR amplifications, and 1… (full text at CIViC)

PMID 22042947 · Lennerz et al., 2011 · Open in CIViC

Cabozantinib's effect on cell proliferation was studied in a variety of cell lines. In two gastric adenocarcinoma cell lines with MET amplification (SNU-5 and Hs746T) were the most sensitive to caboz… (full text at CIViC)

PMID 21926191 · Yakes et al., 2011 · Open in CIViC

Functional studies show that MET activation confers resistance to anti-EGFR therapy both in vitro and in vivo. Notably, in patient-derived colorectal cancer xenografts, MET amplification correlated wi… (full text at CIViC)

PMID 23729478 · Bardelli et al., 2013 · Open in CIViC

7 patients with acquired resistance to EGFR inhibitors were analyzed in this study. Of these, 4 did not develop KRAS mutations. Post- and Pre-Treatment tissued was available of three patients and MET … (full text at CIViC)

PMID ·

4 patient-derived cell lines with MET exon 14 skipping mutation were selected from 50 patient derived tumor lines from the SMC Biomarker study. These cell lines tested against crizotinib, which showed… (full text at CIViC)

PMID 26375439 · Lee et al., 2015 · Open in CIViC

4 patient-derived cell lines with MET exon 14 skipping mutation were selected from 50 patient derived tumor lines from the SMC Biomarker study. These cell lines tested against crizotinib, which showed… (full text at CIViC)

PMID 26375439 · Lee et al., 2015 · Open in CIViC

In this randomised, double-blind, placebo-controlled phase 3 trial, 609 patients with MET+ (expression of at least 1+ intensity on 25% or more tumor cells) gastric cancer or gastroesophageal adenocarc… (full text at CIViC)

PMID 28958504 · Catenacci et al., 2017 · Open in CIViC

Researchers examined the prognostic role of miR-218 expression in CRC tumor samples when receiving 5-FU based treatment. CRC samples from patients who received first-line 5-FU-based adjuvant chemother… (full text at CIViC)

PMID 26442524 · Li et al., 2015 · Open in CIViC

Researchers examined the overall and progression free survival of CRC patients receiving first line 5-Fluorouracil therapy. Samples were stratified into two groups (low/high expressing miR-218). Kapl… (full text at CIViC)

PMID 26442524 · Li et al., 2015 · Open in CIViC

The study found mir-218 was significantly under-expressed when compared to matched adjacent normal tissue in 107 samples via qPCR. Further, low expression of mir-218 was revealed to be associated with… (full text at CIViC)

PMID 26662432 · Li et al., 2015 · Open in CIViC

MLH1 A424T (c.1270G>A), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 45 year old male patient (id: sLS-13) with suspected Lynch Syndrome (LS). Th… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This variant (A681V), identified in a case of microsatellite-unstable colorectal cancer was confirmed to be somatic in a 52 year-old male patient with suspected Lynch Syndrome (LS). The patient was th… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 c.790+1G > A, identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 61 year old male patient (sLS-2) with suspected Lynch Syndrome (LS). The patient … (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This variant (D667fs), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 68 year old female patient (id: sLS-7) with suspected Lynch Syndrome (LS). Th… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

46 patients with poorly cohesive, signet-cell ring, gastric carcinoma were evaluated for genetic mutations and MLH1 expression (immunohistochemistry). Overall survival rate of MLH1 negative cases were… (full text at CIViC)

PMID 27313181 · Rokutan et al., 2016 · Open in CIViC

This variant (G65D), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 71 year-old male patient (sLS-21) with suspected Lynch Syndrome (LS). The patie… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This variant (G67R), identified in a case of microsatellite-unstable colorectal cancer was confirmed to be somatic in a 61 year-old male patient (sLS-18) with suspected Lynch Syndrome (LS). The patien… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 I68S (c.203 T > G), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 65 year old male patient (id: sLS-20) with suspected Lynch Syndrome (LS). T… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 K618del (c.1852_1854del), identified in two cases of microsatellite-unstable colorectal cancer, was confirmed to be somatic in both patients with suspected Lynch Syndrome (LS). Both patients were… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

MLH1 M1L (c.1A>T), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 73 year old female patient (patient id: sLS-8) with suspected Lynch Syndrome (LS)… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

The methylation status of MLH1 was analyzed in a study of 53 paraffin-embedded gastric cancer samples. No association was found between methylation status and clinical factors. The study showed that M… (full text at CIViC)

PMID 24748501 · Li et al., 2015 · Open in CIViC

MLH1 N551T (c.1652A > C) identified in a case of microsatellite-unstable colorectal cancer was confirmed to be somatic in a 51 year old female patient (id: sLS-12) with suspected Lynch Syndrome (LS). … (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC

This variant (P138T), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be a somatic mutation in a 58 year-old male patient (sLS-23) with suspected Lynch syndrome (LS… (full text at CIViC)

PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC