<a class="ci-mono font-sans text-ink no-underline hover:text-accent" href="/gene/NTRK1">NTRK1 Fusion

Predictive

Supports Sensitivity Response

accepted

EID2960

A gene fusion between exon 11 of LMNA and exon 10 of NTRK1 was observed in a patient with metastatic colorectal cancer after therapy with first-line FOLFOX, second-line FOLFIRI/cetuximab, and third-li… (full text at CIViC)

PMID 26546295 · Russo et al., 2016 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 G595R AND NTRK1 G667C

Predictive

Supports Resistance

accepted

EID2961

A gene fusion between exon 10 of NTRK1 and exon 11 of the LMNA genes was observed in a patient with metastatic colorectal cancer after therapy with first-line FOLFOX, second-line FOLFIRI/cetuximab, an… (full text at CIViC)

PMID 26546295 · Russo et al., 2016 · Open in CIViC

Infantile Fibrosarcoma1
LMNA::NTRK1 Fusion	Crizotinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID8878 A mass found at birth in a patient’s left arm became enlarged at age 2 and was resected and characterized as a high-grade spindle cell sarcoma. FISH and RT-PCR did not detect any common sarcoma transl… (full text at CIViC) PMID 30709876 · Bender et al., 2019 · Open in CIViC	civic

Infantile Fibrosarcoma1

LMNA::NTRK1 Fusion

Crizotinib

Predictive

Supports Sensitivity Response

accepted

EID8878

A mass found at birth in a patient’s left arm became enlarged at age 2 and was resected and characterized as a high-grade spindle cell sarcoma. FISH and RT-PCR did not detect any common sarcoma transl… (full text at CIViC)

PMID 30709876 · Bender et al., 2019 · Open in CIViC

Malignant Colorectal Neoplasm2

Malignant Colorectal Neoplasm2
LMNA::NTRK1 Fusion	(oncogenic)	Oncogenic	D	Supports Oncogenicity	1	accepted	EID8901 FISH of the tumor and patient derived xenograft of a 75-year-old with metastatic colorectal cancer that spread to the liver indicated NTRK1 involvement. 5’RACE PCR discovered a novel LMNA-NTRK1 fusion… (full text at CIViC) PMID 26563355 · Sartore-Bianchi et al., 2016 · Open in CIViC	civic
LMNA::NTRK1 Fusion	Entrectinib	Predictive	C	Supports Sensitivity Response	4	accepted	EID8900 After disease progression with no objective response to therapy, a 75-year-old with metastatic colorectal cancer that spread to the liver displayed elevated NTRK1 expression in both primary tumor and … (full text at CIViC) PMID 26563355 · Sartore-Bianchi et al., 2016 · Open in CIViC	civic

LMNA::NTRK1 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

accepted

EID8901

FISH of the tumor and patient derived xenograft of a 75-year-old with metastatic colorectal cancer that spread to the liver indicated NTRK1 involvement. 5’RACE PCR discovered a novel LMNA-NTRK1 fusion… (full text at CIViC)

PMID 26563355 · Sartore-Bianchi et al., 2016 · Open in CIViC

LMNA::NTRK1 Fusion

Predictive

Supports Sensitivity Response

accepted

EID8900

After disease progression with no objective response to therapy, a 75-year-old with metastatic colorectal cancer that spread to the liver displayed elevated NTRK1 expression in both primary tumor and … (full text at CIViC)

PMID 26563355 · Sartore-Bianchi et al., 2016 · Open in CIViC

Malignant Neoplasm15
LMNA::NTRK1 Fusion	Entrectinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID10095 BaF3 cells were transduced with a number of NTRK fusions. IC50 values were measured following treatment with entrectinib: TPM3-NTRK1 (2.5nM), LMNA-NTRK1 (1.4nM), ETV6-NTRK1 (2.5nM), VCL-NTRK2 (4.3nM),… (full text at CIViC) PMID 26884591 · Drilon et al., 2016 · Open in CIViC	civic
LMNA::NTRK1 Fusion	Entrectinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID11354 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, the ent… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion	Larotrectinib	Predictive	D	Supports Sensitivity Response	2	accepted	EID11349 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, the fir… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion	Repotrectinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID11346 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, repotre… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 F589L	Entrectinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID11355 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, the ent… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 F589L	Larotrectinib	Predictive	D	Supports Resistance	3	accepted	EID11351 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, the fir… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 F589L	Repotrectinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID11348 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, repotre… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 G595R	Entrectinib	Predictive	D	Supports Resistance	3	accepted	EID11356 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, entrec… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 G595R	Larotrectinib	Predictive	D	Supports Resistance	3	accepted	EID11350 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, the fir… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 G595R	Repotrectinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID11347 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, repotre… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 G595R AND NTRK1 F589L	Entrectinib	Predictive	D	Supports Resistance	3	accepted	EID11358 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, entrec… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 G595R AND NTRK1 F589L	Larotrectinib	Predictive	D	Supports Resistance	3	rejected	EID11352 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, larotre… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 G595R AND NTRK1 F589L	Larotrectinib	Predictive	D	Supports Resistance	3	accepted	EID11353 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, larotre… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 G667C	Entrectinib	Predictive	D	Supports Resistance	3	accepted	EID11357 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, entrec… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND NTRK1 G667C	Larotrectinib	Predictive	D	Supports Resistance	3	accepted	EID11359 In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, the fir… (full text at CIViC) PMID 34625502 · Murray et al., 2021 · Open in CIViC	civic

Malignant Neoplasm15

LMNA::NTRK1 Fusion

Predictive

Supports Sensitivity Response

accepted

EID10095

BaF3 cells were transduced with a number of NTRK fusions. IC50 values were measured following treatment with entrectinib: TPM3-NTRK1 (2.5nM), LMNA-NTRK1 (1.4nM), ETV6-NTRK1 (2.5nM), VCL-NTRK2 (4.3nM),… (full text at CIViC)

PMID 26884591 · Drilon et al., 2016 · Open in CIViC

LMNA::NTRK1 Fusion

Predictive

Supports Sensitivity Response

accepted

EID11354

In a head-to-head comparison of 4 NTRK inhibitors (larotrectinib, entrectinib, repotrectinib, and selitrectinib) with Ba/F3 cells harboring LMNA::NTRK1 with or without kinase domain mutations, the ent… (full text at CIViC)

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion

Predictive

Supports Sensitivity Response

accepted

EID11349

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion

Repotrectinib

Predictive

Supports Sensitivity Response

accepted

EID11346

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 F589L

Predictive

Supports Sensitivity Response

accepted

EID11355

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 F589L

Predictive

Supports Resistance

accepted

EID11351

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 F589L

Repotrectinib

Predictive

Supports Sensitivity Response

accepted

EID11348

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 G595R

Predictive

Supports Resistance

accepted

EID11356

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 G595R

Predictive

Supports Resistance

accepted

EID11350

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 G595R

Repotrectinib

Predictive

Supports Sensitivity Response

accepted

EID11347

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 G595R AND NTRK1 F589L

Predictive

Supports Resistance

accepted

EID11358

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 G595R AND NTRK1 F589L

Predictive

Supports Resistance

rejected

EID11352

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 G595R AND NTRK1 F589L

Predictive

Supports Resistance

accepted

EID11353

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 G667C

Predictive

Supports Resistance

accepted

EID11357

PMID 34625502 · Murray et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion AND NTRK1 G667C

Predictive

Supports Resistance

accepted

EID11359

PMID 34625502 · Murray et al., 2021 · Open in CIViC

NTRK-Rearranged Spindle Cell Neoplasm6

NTRK-Rearranged Spindle Cell Neoplasm6
LMNA::NTRK1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	4	accepted	EID6391 A 14-month-old boy presented with a slow-growing, asymptomatic back plaque, which was biopsied and found to have S100 positivity, sparse CD34 staining, and no significant mitotic activity, nuclear ple… (full text at CIViC) PMID 29892662 · Bartenstein et al., 2018 · Open in CIViC	civic
LMNA::NTRK1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID11576 A 31-year-old female presented with a pigmented nodule on her scalp that enlarged in size over a 2-year period. Biopsy demonstrated a fascicular proliferation of bland spindle cells within the dermis … (full text at CIViC) PMID 32519338 · Panse et al., 2021 · Open in CIViC	civic
LMNA::NTRK1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID11577 A 21-year-old man demonstrated intermittent abdominal pain, and a CT scan revealed an abnormal paraspinal lesion. Biopsy revealed a spindle cell mesenchymal tumor with monotonous, bland spindle cells … (full text at CIViC) PMID 32782782 · Dupuis et al., 2020 · Open in CIViC	civic
LMNA::NTRK1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID11650 A 3-year-old girl presented with spots on her right buttock that evolved into lumps. Magnetic resonance imaging showed diffuse subcutaneous tissue thickening without significant involvement of underly… (full text at CIViC) PMID 32299759 · Malik et al., 2020 · Open in CIViC	civic
LMNA::NTRK1 Fusion	Entrectinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID11578 A 21-year-old man demonstrated intermittent abdominal pain, and a CT scan revealed an abnormal paraspinal lesion. IHC was positive for CD34, S-100, and pan-TRK and negative for Sox10. Anchored multip… (full text at CIViC) PMID 32782782 · Dupuis et al., 2020 · Open in CIViC	civic
LMNA::NTRK1 Fusion AND S100B Expression	(diagnostic)	Diagnostic	C	Supports Positive	2	submitted	EID12006 Among pediatric fibroblastic and myofibroblastic proliferating superficial lesions, lipofibromatosis (LPF), composed of an admixture of adipose tissue and fibroblastic elements, has been variously cla… (full text at CIViC) PMID 27259011 · Agaram et al., 2016 · Open in CIViC	civic

LMNA::NTRK1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID6391

A 14-month-old boy presented with a slow-growing, asymptomatic back plaque, which was biopsied and found to have S100 positivity, sparse CD34 staining, and no significant mitotic activity, nuclear ple… (full text at CIViC)

PMID 29892662 · Bartenstein et al., 2018 · Open in CIViC

LMNA::NTRK1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID11576

A 31-year-old female presented with a pigmented nodule on her scalp that enlarged in size over a 2-year period. Biopsy demonstrated a fascicular proliferation of bland spindle cells within the dermis … (full text at CIViC)

PMID 32519338 · Panse et al., 2021 · Open in CIViC

LMNA::NTRK1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID11577

A 21-year-old man demonstrated intermittent abdominal pain, and a CT scan revealed an abnormal paraspinal lesion. Biopsy revealed a spindle cell mesenchymal tumor with monotonous, bland spindle cells … (full text at CIViC)

PMID 32782782 · Dupuis et al., 2020 · Open in CIViC

LMNA::NTRK1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID11650

A 3-year-old girl presented with spots on her right buttock that evolved into lumps. Magnetic resonance imaging showed diffuse subcutaneous tissue thickening without significant involvement of underly… (full text at CIViC)

PMID 32299759 · Malik et al., 2020 · Open in CIViC

LMNA::NTRK1 Fusion

Predictive

Supports Sensitivity Response

accepted

EID11578

A 21-year-old man demonstrated intermittent abdominal pain, and a CT scan revealed an abnormal paraspinal lesion. IHC was positive for CD34, S-100, and pan-TRK and negative for Sox10. Anchored multip… (full text at CIViC)

PMID 32782782 · Dupuis et al., 2020 · Open in CIViC

LMNA::NTRK1 Fusion AND S100B Expression

(diagnostic)

Diagnostic

Supports Positive

submitted

EID12006

Among pediatric fibroblastic and myofibroblastic proliferating superficial lesions, lipofibromatosis (LPF), composed of an admixture of adipose tissue and fibroblastic elements, has been variously cla… (full text at CIViC)

PMID 27259011 · Agaram et al., 2016 · Open in CIViC

Sarcoma2
LMNA::NTRK1 Fusion	Larotrectinib	Predictive	C	Supports Sensitivity Response	2	accepted	EID2955 LOXO-101 is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors. The tumor of a 41-year-old woman with soft-tissue sarcoma metastatic to the… (full text at CIViC) PMID 26216294 · Doebele et al., 2015 · Open in CIViC	civic
LMNA::NTRK1 Fusion	Larotrectinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID6100 One Patient with soft tissue sarcoma and a NTRK1-LMNA fusion had a partial response with larotrectinib. Treatment was done within a multicentre, open-label, phase 1/2 study and enrolled infants, child… (full text at CIViC) PMID 29606586 · Laetsch et al., 2018 · Open in CIViC	civic

Sarcoma2

LMNA::NTRK1 Fusion

Predictive

Supports Sensitivity Response

accepted

EID2955

LOXO-101 is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors. The tumor of a 41-year-old woman with soft-tissue sarcoma metastatic to the… (full text at CIViC)

PMID 26216294 · Doebele et al., 2015 · Open in CIViC

LMNA::NTRK1 Fusion

Predictive

Supports Sensitivity Response

accepted

EID6100

One Patient with soft tissue sarcoma and a NTRK1-LMNA fusion had a partial response with larotrectinib. Treatment was done within a multicentre, open-label, phase 1/2 study and enrolled infants, child… (full text at CIViC)

PMID 29606586 · Laetsch et al., 2018 · Open in CIViC

Solid Neoplasm1
LMNA::NTRK1 Fusion	Larotrectinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID9588 One patient was identified with a LMNA-NTRK1 positive tumor in this Phase I study (NCT02122913), which involved 70 heavily pretreated patients with a median age of 59.5 years, with multiple solid tumo… (full text at CIViC) PMID 30624546 · Hong et al., 2019 · Open in CIViC	civic

Solid Neoplasm1

LMNA::NTRK1 Fusion

Predictive

Supports Sensitivity Response

accepted

EID9588

One patient was identified with a LMNA-NTRK1 positive tumor in this Phase I study (NCT02122913), which involved 70 heavily pretreated patients with a median age of 59.5 years, with multiple solid tumo… (full text at CIViC)

PMID 30624546 · Hong et al., 2019 · Open in CIViC

Spindle Cell Sarcoma1
LMNA::NTRK1 Fusion	TRK Inhibitor	Predictive	C	Supports Sensitivity Response	3	accepted	EID8902 A 40-year-old patient with a left calf mass revealed by biopsy to be a low grade myxoid spindle cell carcinoma underwent surgery and radiotherapy. Over a 5-year period, the patient experienced 3 lung … (full text at CIViC) PMID 32050835 · So et al., 2020 · Open in CIViC	civic

Spindle Cell Sarcoma1

LMNA::NTRK1 Fusion

TRK Inhibitor

Predictive

Supports Sensitivity Response

accepted

EID8902

A 40-year-old patient with a left calf mass revealed by biopsy to be a low grade myxoid spindle cell carcinoma underwent surgery and radiotherapy. Over a 5-year period, the patient experienced 3 lung … (full text at CIViC)

PMID 32050835 · So et al., 2020 · Open in CIViC

Spitzoid Melanoma2
LMNA::NTRK1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID8904 A total of 140 Spitzoid neoplasm cases were analyzed by FISH and/or targeted DNA and RNA sequencing (n=38). Mutually exclusive kinase fusions were found in 72 cases. NTRK1 fusions were observed in 23 … (full text at CIViC) PMID 24445538 · Wiesner et al., 2014 · Open in CIViC	civic
LMNA::NTRK1 Fusion	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	accepted	EID8903 The in-frame LMNA-NTRK1 fusion (exon 2 & exon 11) with intact kinase domain was found and confirmed by next generation sequencing, RT-PCR, FISH, and/or immunohistochemistry in 3 Spitz neoplasm cases. … (full text at CIViC) PMID 24445538 · Wiesner et al., 2014 · Open in CIViC	civic

Spitzoid Melanoma2

LMNA::NTRK1 Fusion

(diagnostic)

Diagnostic

Supports Positive

accepted

EID8904

A total of 140 Spitzoid neoplasm cases were analyzed by FISH and/or targeted DNA and RNA sequencing (n=38). Mutually exclusive kinase fusions were found in 72 cases. NTRK1 fusions were observed in 23 … (full text at CIViC)

PMID 24445538 · Wiesner et al., 2014 · Open in CIViC

LMNA::NTRK1 Fusion

(oncogenic)

Oncogenic

Supports Oncogenicity

accepted

EID8903

The in-frame LMNA-NTRK1 fusion (exon 2 & exon 11) with intact kinase domain was found and confirmed by next generation sequencing, RT-PCR, FISH, and/or immunohistochemistry in 3 Spitz neoplasm cases. … (full text at CIViC)

PMID 24445538 · Wiesner et al., 2014 · Open in CIViC