MLH1 P138T

CI-VAR-00005093Explore in graph →CIViC 734

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
MLH1 P138T	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	rejected	EID1797 This variant (P138T), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be a somatic mutation in a 58 year-old male patient (sLS-23) with suspected Lynch syndrome (LS… (full text at CIViC) PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.