MLH1 A424T

CI-VAR-00000099Explore in graph →NP_000240.1:p.Ala424ThrNM_000249.3:c.1270G>AClinVar 220203 CIViC 752 rs377433038

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
MLH1 A424T	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	accepted	EID1816 MLH1 A424T (c.1270G>A), identified in a case of microsatellite-unstable colorectal cancer, was confirmed to be somatic in a 45 year old male patient (id: sLS-13) with suspected Lynch Syndrome (LS). Th… (full text at CIViC) PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
220203	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Hereditary nonpolyposis colorectal neoplasms; Hereditary cancer-predisposing syndrome; Colorectal cancer, hereditary nonpolyposis, type 2; Lynch syndrome; Mismatch repair cancer syndrome 1; Muir-Torré syndrome	germline	14	Feb 03, 2026