MLH1 G67R

CI-VAR-00001785Explore in graph →NP_000240.1:p.Gly67ArgNM_000249.3:c.199G>AClinVar 89992 CIViC 757 rs63750206

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
MLH1 G67R	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	accepted	EID1821 This variant (G67R), identified in a case of microsatellite-unstable colorectal cancer was confirmed to be somatic in a 61 year-old male patient (sLS-18) with suspected Lynch Syndrome (LS). The patien… (full text at CIViC) PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
89992	Pathogenic	reviewed by expert panel	3	Lynch syndrome; Hereditary cancer-predisposing syndrome; Colorectal cancer, hereditary nonpolyposis, type 2; Hereditary nonpolyposis colorectal neoplasms; Lynch-like syndrome; Hereditary nonpolyposis colon cancer; Lynch syndrome 1; Carcinoma of colon	germline/somatic	26	Sep 05, 2013