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CancerIndex

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Core Binding Factor Acute Myeloid Leukemia · CancerIndex

Cancers
Neoplasm
Neoplasm by Special Category
Malignant Neoplasm
Leukemia
Acute Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia with Genetic Abnormalities
Core Binding Factor Acute Myeloid Leukemia

Hematologic Malignancy

Core Binding Factor Acute Myeloid Leukemia

CI-CAN-00008828Explore in graph →

Hematologic6 active trials8 evidence items

NCIt: C122688
DOID: 0080796

Overview
Statistics
Survival
Genomics
Variants & evidence8
Drugs
Trials175
Research
Rankings
Sources & provenance

Data completeness3 / 7 dimensions

Epidemiology (no data yet)
Survival (no data yet)
Trials (data present)
Literature (data present)
Genomics (no data yet)
Evidence (data present)
Therapies (no data yet)

Computed from entity_counters.completeness · refreshed after each connector run

Definition

What this entity is

Acute myeloid leukemia characterized by the presence of t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22). These cytogenetic abnormalities result in disruption of the transcription factor CBF, which is a regulator of normal hematopoiesis.

Definition text as published by ncit-evsProvenance

Source: NCI Thesaurus (NCIt)
Dataset: NCI Thesaurus
Version: 26.08e
Retrieved: Sep 8, 2026
Layer: raw (as published)
Evidence: expert curation
License: CC BY 4.0
Run: ING-NCITEVS-20260908-000001

Open at source Curated

Data updated 22 days agoSource updated 26.08e

Taxonomy

Position in the hierarchies

Several hierarchies coexist; edges are listed per hierarchy type with their source.

Parents

ncit

Acute Myeloid Leukemia with Genetic AbnormalitiesHematologic Malignancy

Children (2)

ncit

Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH112 sub
Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T12 sub

8 descendants in total; counters on this page aggregate over all of them.

Anatomy

Anatomical sites

Hematopoietic and Lymphatic SystemC35813

Record

Identity

CancerIndex ID: CI-CAN-00008828
Entity type: Hematologic Malignancy
Malignant: Yes
Solid / hematologic: Hematologic
Pediatric relevant: Not flagged
Rare cancer: Unknown (no incidence data yet)
Hierarchy depth: 8
Classification version: 26.08e
Semantic types: Neoplastic Process
Status: Active
Record updated: 2026-09-08

Coverage

Data completeness

Trials (all / active)

175 / 6

Publications (all / 5y)

311 / 121

Evidence items

8

Genes / variants

2 / 2

Drugs (any / approved)

0 / 0

Genomic cohorts

0

Epidemiology / survival obs.

0 / 0

Data updated 18 hours agoSource updated unknowncounters aggregate over descendants

Names

Synonyms (2)

CBF-AMLsynonym · NCIt
Core Binding Factor Acute Myeloid Leukemiasynonym · CIViC

CancerIndex is a research and information platform. It does not diagnose and does not recommend treatment.

Key figures

At a glance

Each figure carries its unit, period and source; ranks link to "Why this rank?".

US deaths23,740countUnited States · 2024 · both sexes · all agescdc-wonderObservedrank #7 of 31 (USA · both sexes · all ages · 2024 · top-level cancers)figures shown for Leukemia (registry level) — open Leukemia
US new cases58,254countUnited States · 2023 · both sexes · all agescdc-uscsObservedrank #11 of 32 (USA · both sexes · all ages · 2023 · top-level cancers)figures shown for Leukemia (registry level) — open Leukemia
US age-standardized mortality5.5per 100,000United States · 2024 · both sexes · all ages · 2000 U.S. Std. Populationcdc-wonderObservedrank #6 of 23 (USA · both sexes · all ages · 2024 · top-level cancers)figures shown for Leukemia (registry level) — open Leukemia
Active trials6countcurrent registry status · entity + descendantsclinicaltrialsComputedrank #703 of 1,654 (World · both sexes · all ages · latest · all malignant entities)
Recruiting trials4countstatus RECRUITING · entity + descendantsclinicaltrialsComputedrank #633 of 1,277 (World · both sexes · all ages · latest · all malignant entities)
Curated evidence items8countaccepted CIViC items · entity + descendantscivicComputedrank #213 of 492 (World · both sexes · all ages · latest · all malignant entities)
Publications, last 12 months26countPubMed records · stored query · 12-month windowpubmedComputedrank #642 of 2,294 (World · both sexes · all ages · latest · all malignant entities)
Genomic cohorts0countopen GDC projects · entity + descendantsgdcComputednot in a current ranking snapshot

Data updated 18 hours agoSource updated unknownregistry figures: cdc-uscs · latest year available per metric · counters aggregate over descendants