Variant · Fusion
DUX4 Fusion
CI-VAR-00001304Explore in graph →CIViC 3252
Curated evidence
Evidence by cancer (5 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28346326
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CIC-Rearranged Sarcoma5 | ||||||||
| CIC::DUX4 Fusion | (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID9012This study consists of a cohort of 115 patients with a class of sarcomas that had similar morphology to Ewing sarcoma. The presence of a CIC rearrangement was detected in all the cases by FISH. Previo… (full text at CIViC) PMID 28346326 · Antonescu et al., 2017 · Open in CIViC | civic |
| CIC::DUX4 Fusion | (diagnostic) | Diagnostic | B | Supports Positive | 3 | accepted | EID11594The authors recognize that differentiating between Ewing sarcoma and CIC::DUX4 fusion associated sarcoma can be challenging due to overlapping histological and immunohistochemical phenotypes. In this… (full text at CIViC) PMID 35151033 · Song et al., 2022 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available