Cancer Family
Carcinoma
CI-CAN-00000114Explore in graph →
7,363 active trials118 approved drugs1,149 evidence items
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Cancer Family
CI-CAN-00000114Explore in graph →
Genomics
305 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
88 cases with simple somatic mutation data · 88 cases total · 2026-01-07 · mapped to Esophageal Squamous Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 73 |
| 88 |
| 83% |
| cbioportal |
| 2 | TTN | Ssm | 28 | 88 | 31.8% | cbioportal |
| 3 | MUC16 | Ssm | 12 | 88 | 13.6% | cbioportal |
| 4 | PCLO | Ssm | 12 | 88 | 13.6% | cbioportal |
| 5 | ZFHX4 | Ssm | 11 | 88 | 12.5% | cbioportal |
| 6 | LRP1B | Ssm | 10 | 88 | 11.4% | cbioportal |
| 7 | DMD | Ssm | 8 | 88 | 9.1% | cbioportal |
| 8 | NOTCH1 | Ssm | 8 | 88 | 9.1% | cbioportal |
| 10 | DNAH6 | Ssm | 7 | 88 | 8% | cbioportal |
| 9 | CSMD3 | Ssm | 7 | 88 | 8% | cbioportal |
| 13 | SYNE1 | Ssm | 7 | 88 | 8% | cbioportal |
| 12 | RB1 | Ssm | 7 | 88 | 8% | cbioportal |
| 11 | PKHD1L1 | Ssm | 7 | 88 | 8% | cbioportal |
| 23 | RYR2 | Ssm | 6 | 88 | 6.8% | cbioportal |
| 16 | DNAH14 | Ssm | 6 | 88 | 6.8% | cbioportal |
| 21 | MACF1 | Ssm | 6 | 88 | 6.8% | cbioportal |
| 14 | ADGRV1 | Ssm | 6 | 88 | 6.8% | cbioportal |
| 24 | USH2A | Ssm | 6 | 88 | 6.8% | cbioportal |
| 18 | FAM135B | Ssm | 6 | 88 | 6.8% | cbioportal |
| 17 | DNAH17 | Ssm | 6 | 88 | 6.8% | cbioportal |
| 15 | CACNA1E | Ssm | 6 | 88 | 6.8% | cbioportal |
| 19 | FAT3 | Ssm | 6 | 88 | 6.8% | cbioportal |
| 20 | FAT4 | Ssm | 6 | 88 | 6.8% | cbioportal |
| 22 | RP1 | Ssm | 6 | 88 | 6.8% | cbioportal |
| 37 | ZNF750 | Ssm | 5 | 88 | 5.7% | cbioportal |
| 26 | ADGB | Ssm | 5 | 88 | 5.7% | cbioportal |
| 28 | COL24A1 | Ssm | 5 | 88 | 5.7% | cbioportal |
| 33 | MAGEC3 | Ssm | 5 | 88 | 5.7% | cbioportal |
| 29 | COL6A3 | Ssm | 5 | 88 | 5.7% | cbioportal |
| 30 | CREBBP | Ssm | 5 | 88 | 5.7% | cbioportal |
Data updated 22 days agoSource updated 2026-01-07