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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
691 stopped studies mapped to Malignant Head and Neck Neoplasm and descendants · 92% state a reason
Over the 691 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01820312 | A Phase II Study to Evaluate Low-Dose Fractionated Radiotherapy (LDFRT) | Phase 2 | withdrawn | Mar 28, 2013 | University of Arkansas | Due to no enrollment. | Enrollment / accrual |
| NCT01528137 | Talactoferrin in Treating Patients With Relapsed or Refractory Non-Small Cell Lung Cancer… | Phase 1 | terminated | Feb 7, 2012 | Stanford University | Negative data from another trial led to termination of this trial by sponsor. | Other (stated, no rule matched) |
| NCT02334319 | Ganetespib Window of Opportunity Study in Head and Neck Cancers | Phase 1 | terminated | Jan 8, 2015 | Emory University | Lack of funding | Funding |
| NCT01137162 | Clinical and Pathologic Studies of Patients Undergoing Treatment With EGFR Inhibitors | — | terminated | Jun 4, 2010 | Stanford University | Low Accrual | Enrollment / accrual |
| NCT00627835 | Dose Escalation Trial of Neoadjuvant Sorafenib and Concurrent Sorafenib, Cisplatin and… | Phase 1 | withdrawn | Mar 3, 2008 | British Columbia Cancer Agency | Site decided not to open this study | Other (stated, no rule matched) |
| NCT01403324 | Comparison of Dosimetry After rhTSH or Withdrawal of Thyroid Hormone in Metastatic or…(DOSIMETA) | N/A | terminated | Jul 27, 2011 | Gustave Roussy, Cancer Campus, Grand Paris | Recruitment difficulties | Enrollment / accrual |
| NCT00041171 | Docetaxel and St. John's Wort in Treating Patients With Solid Tumors That Cannot Be… | Phase 3 | withdrawn | Jan 27, 2003 | Alliance for Clinical Trials in Oncology | The study was not activated. | Other (stated, no rule matched) |
| NCT00377247 | Active Immunization of Patients With Carcinoma of Oral Cavity or Oropharynx With… | Phase 1 | terminated | Sep 18, 2006 | University of Pittsburgh | study closed to accrual due to slow accrual | Enrollment / accrual |
| NCT02080416 | Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors | Early Phase 1 | terminated | Mar 6, 2014 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Very slow accrual; terminated to allow resources to be utilized more effectively on other studies.… | Enrollment / accrual |
| NCT01184027 | Impact of Nutrition and Swallowing Function of Head and Neck Cancer Patients During the… | — | withdrawn | Aug 18, 2010 | University of Alberta | The study did not receive funding. | Funding |
| NCT00537199 | OraTest in Combination With Visual Examination and Visual Examination Alone | Phase 3 | terminated | Sep 28, 2007 | M.D. Anderson Cancer Center | Study terminated early as per request by sponsor, Zila Biotechnology, Inc. | Other (stated, no rule matched) |
| NCT02119728 | Photodynamic Therapy With HPPH in Treating Patients With Squamous Cell Carcinoma of the… | Phase 2 | withdrawn | Apr 22, 2014 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT02143622 | Study of Efficacy and Safety of LJM716 and Cetuximab in Head and Neck Squamous Cell… | Phase 1 / Phase 2 | withdrawn | May 21, 2014 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00872404 | A Study of CP-751,871 in Patients With Recurrent Squamous Head and Neck Carcinoma | Phase 2 | terminated | Mar 31, 2009 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | lack of efficacy | Efficacy / futility |
| NCT00623129 | Electroacupuncture in Treating Chronic Dry Mouth Caused By Radiation Therapy in Patients… | N/A | terminated | Feb 25, 2008 | Mayo Clinic | Slow accrual; did not meet accrual goal | Enrollment / accrual |
| NCT00891904 | Radiation Therapy and Cetuximab in Treating Patients With Recurrent Head and Neck Cancer | N/A | terminated | May 1, 2009 | Roswell Park Cancer Institute | Low accrual | Enrollment / accrual |
| NCT02479178 | A Study of BIND-014 in Patients With Urothelial Carcinoma, Cholangiocarcinoma, Cervical…(iNSITE2) | Phase 2 | terminated | Jun 24, 2015 | BIND Therapeutics | not stated | Not stated |
| NCT01285635 | A Study of AT-101 in Combination With Docetaxel in Squamous Cell Carcinoma Of The Head… | Phase 2 | terminated | Jan 28, 2011 | University of Michigan Rogel Cancer Center | drug is no longer manufactured | Drug supply |
| NCT00994201 | Magnetic Resonance Imaging (MRI) in the Assessment of Head and Neck Squamous Cell… | — | terminated | Oct 14, 2009 | OHSU Knight Cancer Institute | Study never accrued sufficient subjects | Enrollment / accrual |
| NCT00670397 | Photodynamic Therapy Using HPPH in Treating Patients With Recurrent Dysplasia, Carcinoma… | Phase 1 | terminated | May 1, 2008 | Roswell Park Cancer Institute | safety issues | Safety / toxicity |
| NCT00375700 | Effect of an Oral Supplement on the Total Energy and Protein Intake of Head and Neck… | N/A | withdrawn | Sep 13, 2006 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT01994200 | Developing and Implementing an Interdisciplinary Team-Based Care Approach (ITCA-ThyCa)…(ITCA-ThyCa) | Phase 1 / Phase 2 | withdrawn | Nov 25, 2013 | Jewish General Hospital | not stated | Not stated |
| NCT01161498 | Study of Safety and Efficacy of Talimogene Laherparepvec With Cisplatin and Radiotherapy… | Phase 3 | terminated | Jul 13, 2010 | BioVex Limited | The changing aetiology of squamous cell carcinoma of the head and neck (SCCHN). | Other (stated, no rule matched) |
| NCT02516774 | A Trial of Adalimumab Combined to Chemotherapy and Radiotherapy in Patients With…(TAM-RT) | Phase 1 | withdrawn | Aug 6, 2015 | Gustave Roussy, Cancer Campus, Grand Paris | No patients enrolled | Enrollment / accrual |
| NCT00984217 | Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies | Phase 2 | withdrawn | Sep 25, 2009 | University of Pittsburgh | Decided not to pursue at UPCI | Other (stated, no rule matched) |
| NCT00272181 | Study of Proxinium for Treating Patients With Squamous Cell Head and Neck Cancer | Phase 2 | terminated | Jan 4, 2006 | Sesen Bio, Inc. | Slow accrual in North America | Enrollment / accrual |
| NCT00412776 | Study of Proxinium Plus Best Supportive Care Versus Best Supportive Care for Patients… | Phase 2 / Phase 3 | terminated | Dec 18, 2006 | Sesen Bio, Inc. | Corporate reasons unrelated to safety and efficacy | Safety / toxicity |
| NCT00599131 | Cetuximab and Radiation Therapy in Laryngeal Cancer Patients Who Have Responded to One… | Phase 2 | terminated | Jan 23, 2008 | University of Michigan Rogel Cancer Center | The study was discontinued prematurely due to early stopping rules. | Other (stated, no rule matched) |
| NCT00006994 | S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly… | Phase 3 | terminated | Jan 27, 2003 | SWOG Cancer Research Network | Withdrawn due to drug availability and funding | Drug supply |
| NCT00720083 | Chemotherapy and Radiation Therapy (RT) With or Without Vandetanib in Treating Patients… | Phase 2 | terminated | Jul 22, 2008 | Radiation Therapy Oncology Group | Withdrawal of drug supply. | Drug supply |
| NCT02042885 | A Clinical Trial to Determine the Most Suitable Dose of OPB-111001 in Patients With… | Phase 1 / Phase 2 | terminated | Jan 23, 2014 | Otsuka Novel Products GmbH | not stated | Not stated |
| NCT00214305 | Effects of Swallowing Therapy in Head and Neck Cancer | N/A | withdrawn | Sep 21, 2005 | University of Wisconsin, Madison | low accrual | Enrollment / accrual |
| NCT00002735 | SWOG-9451, Combination Chemo & RT For Patients With Stage III/Stage IV Cancer of the… | Phase 2 | terminated | Sep 1, 2004 | SWOG Cancer Research Network | Terminated due to poor accrual. | Enrollment / accrual |
| NCT01586182 | Stereotactic Boost for Oropharyngeal Squamous Cell Carcinoma | Phase 1 / Phase 2 | withdrawn | Apr 26, 2012 | Dana-Farber Cancer Institute | Local IRB closed the study due to poor accural. | Other (stated, no rule matched) |
| NCT01949740 | Patient Preferences in Making Treatment Decisions in Patients With Stage I-IVA… | — | terminated | Sep 24, 2013 | University of Chicago | Poor accrual | Enrollment / accrual |
| NCT01312493 | Selective IMRT for Locally Advanced Head and Neck Carcinoma With Concurrent Panitumumab | Phase 2 | withdrawn | Mar 10, 2011 | UNC Lineberger Comprehensive Cancer Center | Funding source was terminated before enrollment of first subject | Enrollment / accrual |
| NCT01111942 | A Pilot Study of Induction Chemotherapy Followed by Surgery for Locally Advanced… | Early Phase 1 | terminated | Apr 28, 2010 | Southern Illinois University | lack of enrollment | Enrollment / accrual |
| NCT02058017 | OPB-51602 in Locally Advanced Nasopharyngeal Carcinoma Prior to Definitive… | Phase 1 | terminated | Feb 7, 2014 | National University Hospital, Singapore | Lactic and metabolic acidosis of OPB-51602 is not tolerable | Other (stated, no rule matched) |
| NCT01694576 | NPC Staged N2-3M0:Adjuvant Chemotherapy or Just Observation After Concurrent… | Phase 2 | terminated | Sep 27, 2012 | Jiangsu Cancer Institute & Hospital | slow patient enrollment | Enrollment / accrual |
| NCT00176241 | Phase I Trial of Biweekly Gemcitabine & Paclitaxel & Low-Dose Radiation for Metastatic or… | Phase 1 | terminated | Sep 15, 2005 | Susanne Arnold | Slow accrual | Enrollment / accrual |
| NCT00002999 | S9715, Chemotherapy and Radiation Therapy in Treating Patients With Advanced Cancer of… | Phase 2 | withdrawn | Jul 5, 2004 | SWOG Cancer Research Network | not stated | Not stated |
| NCT01701466 | Neoviderm Skin Emulsion in the Prevention of Radiation Dermatitis | Phase 2 | terminated | Oct 5, 2012 | Sir Mortimer B. Davis - Jewish General Hospital | not stated | Not stated |
| NCT00088907 | Phase III Trial Of Docetaxel Versus Docetaxel Plus ZD1839 In Head And Neck Cancer | Phase 3 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | It was unlikely that the primary endpoint would be reached based on the fifth interim analysis… | Efficacy / futility |
| NCT02156180 | Identification of Breath Biomarkers in Head and Neck Squamous Cell Carcinoma | — | suspended | Jun 5, 2014 | Queensland Centre of Excellence for Head and Neck Cancer | Awaiting funding to facilitate selected-ion flow-tube mass spectrometry (SIFT/MS) | Funding |
| NCT00200408 | Assessment of Early Genetic Changes in Smokers | — | terminated | Sep 20, 2005 | Montefiore Medical Center | unable to obtain funding | Funding |
| NCT01153945 | Association Between Cancer Cells and Normal Versus (Vs.) Low Levels of Thyroid Hormones… | — | withdrawn | Jun 30, 2010 | Meir Medical Center | The sponsor stopped the study. | Other (stated, no rule matched) |
| NCT00881114 | Study Using Pharmacogenetics to Select Treatment for Head and Neck Cancer(PGx-SELECT) | Phase 2 | withdrawn | Apr 15, 2009 | Georgetown University | Investigator decided it was not feasible to conduct this study | Investigator |
| NCT01953952 | Radiation Therapy and Cisplatin With or Without Surgery in Treating Patients With Stage… | Phase 2 | withdrawn | Oct 1, 2013 | Radiation Therapy Oncology Group | Slow accrual | Enrollment / accrual |
| NCT01548846 | Impact of Tomotherapy on Xerostomia and Quality of Life of Patients With Cancer of the…(TOQUAL) | Phase 2 | terminated | Mar 8, 2012 | Centre Francois Baclesse | lack of recrutment | Other (stated, no rule matched) |
| NCT01133262 | Effectiveness in Head and Neck Cancer Detection Using Positron Emission Tomography (PET)… | — | withdrawn | May 28, 2010 | Washington University School of Medicine | Feasibility/pilot study of 5 subjects registration not required | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Aug 8, 2016source: clinicaltrials