Clinical trial · Observational
Assessment of Early Genetic Changes in Smokers
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): unable to obtain funding
Summary
Brief summary (as posted)
This study will look at the genetic profile of cells taken from the oral cavity of healthy college students who smoke and who do not smoke cigarettes. This will be done using a small brush similar to that used in Pap tests for cervical cancer detection. Our aim is to determine if smoking causes early genetic changes in the DNA of these cells such as have been seen in the cells of cancerous tumors of the head and neck area and nearby healthy tissues. This will be correlated with data from subject questionnaires to assess tobacco use, and other behavior and demographic information.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer of Head and Neck | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
| Smoking | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- smokers
- description
- college students who smoke
- label
- non smokers
- description
- college students who don't smoke
Primary outcomes (1)
- measure
- alteration of gene expression profile
- timeFrame
- 2 yrs
- description
- comparison of gene expression profiles between smokers and non-smokers
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: College freshmen and sophomores Smokers must be between the ages of 18 and 25 Smokers must have smoked regularly for at least 2 years and be currently smoking Smokers must intend to stay in the New York area for at least 3 years. Non-smokers must be non-users of marijuana - Exclusion Criteria: Current HIV/AIDS infection Use of chewing tobacco \-
References
Publications (0)
Data not yet available