Ganetespib Window of Opportunity Study in Head and Neck Cancers

Inclusion Criteria:

* Patients must have pathologically-confirmed, resectable, squamous cell carcinoma of the oral cavity, oropharynx, larynx or hypopharynx
* Disease may be stage I, II, III or IVa (as long as it is deemed resectable by the surgical team)
* Tumor must be surgically resectable and curable with conventional surgery
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2
* Patients must give documented informed consent to participate in this study
* Absolute-neutrophil count (ANC) ≥ 1500/mm³
* Platelet count ≥ 100,000/mm³
* Total bilirubin ≤ within upper limit of normal (ULN)
* Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 x ULN
* Creatinine ≤ 1.5 x ULN
* Lipase levels \< 1.5 x ULN
* Amylase levels \< 1.5 x ULN

Exclusion Criteria:

* Prior therapy with a known heat shock protein 90 (HSP90) inhibitor
* Poor venous access for study drug administration; in this case, patients would require a peripheral or central indwelling catheter for study drug administration; study drug administration via indwelling catheters is prohibited at this time unless silicone based catheters are used; anything other than catheters made from silicone are not allowed with ganetespib therapy
* History of severe allergic or hypersensitivity reactions to excipients (e.g., polyethylene glycol \[PEG\] 300 and polysorbate 80)
* Treatment with chronic immunosuppressant (e.g., cyclosporine following transplantation)
* Uncontrolled undercurrent illness including, but not limited to, human immunodeficiency virus (HIV)-positive subjects receiving combination antiretroviral therapy, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, ventricular arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
* Other medications, or severe acute/chronic medical or psychiatric condition, or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the subject inappropriate for entry into this study
* Documented evidence of distant metastases or brain metastases
* Active malignancy besides head and neck squamous cell cancer (HNSCC) or primary skin basal cell carcinoma; (patients with a concomitant malignancy that has not progressed within 12 months of study entry are eligible)
* History of documented congestive heart failure (CHF), New York Heart Association class II/III/IV, with a history of dyspnea, orthopnea or edema that requires current treatment with angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers or diuretics; NOTE: use of these medications for the treatment of hypertension is allowed
* Peripheral neuropathy that is grade 2 or higher
* Pregnancy or lactation; patients of child bearing age must agree to use adequate contraception
* Patients residing in prison
* CARDIAC EXCLUSION CRITERIA:

  * Known serious cardiac illness or medical conditions, including but not limited to:

    * Clinically unstable cardiac disease, including unstable atrial fibrillation, symptomatic bradycardia, unstable congestive heart failure, active myocardial ischemia, or indwelling temporary pacemaker
    * Ventricular tachycardia or a supraventricular tachycardia that requires treatment with a class Ia antiarrhythmic drug (e.g., quinidine, procainamide, disopyramide) or class III antiarrhythmic drug (e.g., sotalol, amiodarone, dofetilide); use of other antiarrhythmic drugs is permitted
    * Use of medications that have been linked to the occurrence of Torsades de pointes
    * Second- or third-degree atrioventricular (AV) block unless treated with a permanent pacemaker
    * Complete left bundle branch block (LBBB)
    * History of long QT syndrome or a family member with this condition
    * Corrected QT (QTc) \> 470 ms (average of triplicate electrocardiogram \[ECG\] recordings); a consistent method of QTc calculation must be used for each patient's QTc measurements; QTcF (Fridericia's formula) is preferred
    * Serum potassium, magnesium, or calcium levels in the following ranges:

      * Potassium \< 3.4 or \> 5.1 mmol/L
      * Magnesium \< 1.4 or \> 2.4 mg/dL
      * Calcium \< 8.9 or \> 10.5 mg/dL