OPB-51602 in Locally Advanced Nasopharyngeal Carcinoma Prior to Definitive Chemoradiotherapy

Inclusion Criteria:

* Part I only: Patients with pathologically confirmed, locally recurrent or metastatic solid tumours who have failed standard treatment options. In the enrichment cohort, NPC patients will be eligible as long as they have received prior platinum-based therapy, either in the curative or metastatic setting. At least one tumour lesion (primary or metastatic) that is suitable for baseline biopsy which is accessible either by free hand or image guided biopsy is required.
* Part II only: Patients with histologically confirmed WHO Type III NPC. Tumour stage III, IVA (T4 N0-2 M0) or IVB (Any T N3 M0) according to the American Joint Committee on Cancer (AJCC) 2010 criteria and planned for definitive chemoradiotherapy (radiotherapy at 70Gy/33# with concurrent IV cisplatin 40mg/m2/week for duration of radiotherapy) as per institutional standards. Patients who are planned for induction chemotherapy followed by concurrent chemoradiotherapy will not be included in the study. Patients receiving alternative chemoradiotherapy regimens may only be considered upon approval of the P.I.
* Age ≥ 21 years at the time of consent
* Eastern Cooperative Oncology Group (ECOG) performance status \< 1
* Life expectancy \> 3 months
* Adequate organ function as defined by:

Bone marrow function

* Haemoglobin ≥ 9g/dl
* Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
* Platelet count ≥ 75 x 109/L. Liver function
* Bilirubin \</= 2.5x upper limit of normal (ULN)
* Alanine transaminase (ALT) and aspartate transaminase (AST) \</= 2.5x ULN or \</= 5x ULN if liver metastases are present
* Prothrombin time (PT) within the normal range for the institution. Renal function
* Plasma creatinine \</=1.5x institutional ULN for part I and calculated creatinine clearance (by the Cockcroft-Gault formula) \> 60mL/min for part II.
* Capable of swallowing OPB-51602 tablets
* Recovery from any previous drug- or procedure-related toxicity to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 4.0 Grade 0 or 1 (except alopecia), or to baseline preceding the prior treatment.
* Signed informed consent obtained before any study specific procedure. Subjects must be able to understand and be willing to sign the written informed consent.

Exclusion Criteria:

* Part I only: Chemotherapy, radiotherapy, surgery, immunotherapy or other therapy within 4 weeks of starting investigational medicinal product (IMP).
* Part II only: Previous or concurrent anti-cancer chemotherapy, immunotherapy, radiotherapy or any other investigational therapy.
* Uncontrolled central nervous system metastasis (applicable to Part I)
* Any concomitant condition that could compromise the objectives of this study and/or the patient's compliance (eg. severe medical conditions such as uncontrolled infection, poorly controlled diabetes mellitus, hypercalcaemia, psychiatric disorders).
* Use of any of the prohibited medications and other substances listed in Appendix 2 (CYP3A4 Inhibitors and Inducers) within 1 week prior to start of study drug administration
* Pregnancy or breastfeeding.
* Women of childbearing potential not employing adequate contraception. Women of childbearing potential must have a pregnancy test performed a maximum of 7 days before start of study medication, and a negative result must be documented before start of study medication. Women of childbearing potential and men, must agree to use adequate contraception (barrier method of birth control) upon signing the informed consent form until at least 3 months after the last study drug administration.
* Known or suspected allergy to the investigational agent or any agent given in association with this study.
* Previous or concurrent cancer which is distinct in primary site or histology from the cancer being evaluated in this study EXCEPT cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumours (Ta, Tis \& T1) or any cancer curatively treated \> 3 years prior to study entry.
* Interstitial lung disease with ongoing signs and symptoms at the time of screening.
* Patients with CTCAE Grade 2 or higher peripheral neuropathy.
* Patients with CTCAE Grade 1 or higher pneumonitis (interstitial pneumonia) or pulmonary fibrosis
* History of significant cardiac disease: congestive cardiac failure \> NYHA class II, ongoing unstable angina, new-onset angina or myocardial infarction within the past 3 months