Loading clinical trials…
Loading clinical trials…
Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
163 stopped studies mapped to Malignant Colon Neoplasm and descendants · 88% state a reason
Over the 163 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computed
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT04044430 | Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E… | Phase 1 | terminated | Aug 5, 2019 | University of California, San Francisco | Sponsor funding | Funding |
| NCT01882660 | Pre-operative Decitabine in Colon Cancer: a Proof of Principle Study(DECO) | N/A | terminated | Jun 20, 2013 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Inclusion of patients was slow. Could not reach the target within the studyperiod. | Other (stated, no rule matched) |
| NCT05178576 | A Single Arm Phase II Study to Evaluate Treatment With Gevokizumab in Patients With Stage… | Phase 2 | withdrawn | Jan 5, 2022 | NSABP Foundation Inc | Study drug not available for the study duration. | Other (stated, no rule matched) |
| NCT05433402 | Repurposing the Antipsychotic Drug Chlorpromazine as Adjuvant Therapeutic Agent for… | Phase 1 / Phase 2 | withdrawn | Jun 27, 2022 | Sadat City University | Organizational safety isues | Safety / toxicity |
| NCT03693846 | Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors | Phase 2 | terminated | Oct 3, 2018 | Abramson Cancer Center at Penn Medicine | Terminated due to slow enrollment and lack of efficacy | Efficacy / futility |
| NCT03827044 | Avelumab Plus 5-FU Based Chemotherapy as Adjuvant Treatment for Stage 3 MSI-High or POLE…(POLEM) | Phase 3 | terminated | Feb 1, 2019 | Royal Marsden NHS Foundation Trust | POLEM encountered significant recruitment challenges. With little prospect of recruiting to target… | Enrollment / accrual |
| NCT03781778 | Pilot Trial of Resistant Starch in Stage I-III Colorectal Cancer Survivors | Phase 2 | terminated | Dec 20, 2018 | Fred Hutchinson Cancer Center | Terminated due to expiration of funding | Funding |
| NCT02363647 | Personalized Cancer Therapy for Patients With Metastatic Medullary Thyroid or Metastatic… | N/A | terminated | Feb 16, 2015 | Icahn School of Medicine at Mount Sinai | No Current Funding | Funding |
| NCT05018325 | Assessing Effect of Withdrawal Time on Adenoma Detection Rate for Screening Colonoscopy | N/A | terminated | Aug 24, 2021 | Washington University School of Medicine | Futility | Efficacy / futility |
| NCT03524820 | Cetuximab Therapy for Third Line Rechallenge in Metastatic Colorectal Cancer | Phase 2 | terminated | May 15, 2018 | Hadassah Medical Organization | By Merck | Other (stated, no rule matched) |
| NCT04685551 | Improving Survivorship Among Minority Cancer Dyads | N/A | withdrawn | Dec 28, 2020 | Charles Drew University of Medicine and Science | Study not funded | Funding |
| NCT03970694 | Neoadjuvant Chemoradiotherapy Versus Neoadjuvant Chemotherapy For Unresectable Locally… | Phase 3 | terminated | May 31, 2019 | Sun Yat-sen University | Significant differences in conversion rate as well as R0 resection rate between the two groups. | Other (stated, no rule matched) |
| NCT03475680 | Mechanical Bowel Preparation and Oral Antibiotics Before Colon Cancer Surgery(COLONPREP) | Phase 3 | terminated | Mar 23, 2018 | Assistance Publique - Hôpitaux de Paris | lack of inclusions | Other (stated, no rule matched) |
| NCT05156463 | The PAI Trial for Breast and Colon Cancer Survivors | N/A | withdrawn | Dec 14, 2021 | Milton S. Hershey Medical Center | Award not yet received and PI is transferring to a different institution | Other (stated, no rule matched) |
| NCT02588248 | L-Menthol Injection as a Novel Technique During Colonoscopy(MINT-C) | Phase 3 | terminated | Oct 27, 2015 | University Hospitals Cleveland Medical Center | Sponsor/Investigator has decided to close out the study | Investigator |
| NCT02628535 | Safety Study of MGD009 in B7-H3-expressing Tumors | Phase 1 | terminated | Dec 11, 2015 | MacroGenics | Business decision (not for safety reasons) | Safety / toxicity |
| NCT01285102 | Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From… | Phase 1 | terminated | Jan 27, 2011 | Fox Chase Cancer Center | This study was closed early by the DSMB due to increased toxicity. | Safety / toxicity |
| NCT03661047 | OMega-3 Fatty Acid for the Immune Modulation of Colorectal Cancer(OMICC) | Phase 2 | withdrawn | Sep 7, 2018 | Massachusetts General Hospital | Study will be closed due to zero enrollment in over 2 years. | Enrollment / accrual |
| NCT01505166 | Randomized Phase II Adjuvant Chemotherapy ± FANG™ in Colorectal Carcinoma With Liver…(FANG-CLM) | Phase 2 | terminated | Jan 6, 2012 | Gradalis, Inc. | Terminated (Business Decision to pursue other indications) | Sponsor / business decision |
| NCT03633539 | Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer(mSILSC) | N/A | withdrawn | Aug 16, 2018 | Ruijin Hospital | No research funds were raised | Funding |
| NCT04511793 | Hepatic Artery Infusion (HAI) Program at Duke University | N/A | withdrawn | Aug 13, 2020 | Michael Lidsky, M.D. | No subjects enrolled due to availability of device commercially. | Enrollment / accrual |
| NCT03137706 | Characterization of Mechanical Tissue Properties in Patients With Pancreatic, Liver, or… | — | terminated | May 3, 2017 | University of Southern California | Insufficient accrual | Enrollment / accrual |
| NCT00578396 | Phase I Biomarker Study of Dietary Grape-derived Low Dose Resveratrol for Colon Cancer… | Phase 1 | withdrawn | Dec 21, 2007 | University of California, Irvine | Non applicable clinical trial | Other (stated, no rule matched) |
| NCT03974984 | Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery(ANIMOX) | — | withdrawn | Jun 5, 2019 | University of Copenhagen | Not feasable due to logistics | Other (stated, no rule matched) |
| NCT04270461 | NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors | Phase 1 | withdrawn | Feb 17, 2020 | Jiujiang University Affiliated Hospital | Study is withdrawn because of administrative reasons | Other (stated, no rule matched) |
| NCT03480152 | Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by… | Phase 1 / Phase 2 | terminated | Mar 29, 2018 | National Cancer Institute (NCI) | slow accrual | Enrollment / accrual |
| NCT01557881 | Positron Emission Tomography/Magnetic Resonance Imaging in Patients | N/A | terminated | Mar 20, 2012 | Case Comprehensive Cancer Center | Funding unavailable | Funding |
| NCT02687009 | A Study of Niclosamide in Patients With Resectable Colon Cancer | Phase 1 | terminated | Feb 22, 2016 | Michael Morse, MD | low accrual | Enrollment / accrual |
| NCT02425683 | Study of Colorectal Cancer Patients (Stage IIIC) With Either Regorafenib or Standard of… | Phase 2 | terminated | Apr 24, 2015 | US Oncology Research | insufficient accrual | Enrollment / accrual |
| NCT03408561 | Social Media Listening in Improving Clinical Trial Recruitment in Patients With Cancer | N/A | withdrawn | Jan 24, 2018 | University of Southern California | No accrual | Enrollment / accrual |
| NCT03682133 | PreColo Practice Variation | — | terminated | Sep 24, 2018 | Radboud University Medical Center | Retrospective part completed, prospective part response too low | Other (stated, no rule matched) |
| NCT00397878 | AZD0530 (NSC 735464) in Treating Patients With Previously Treated Metastatic Colon Cancer… | Phase 2 | terminated | Nov 10, 2006 | National Cancer Institute (NCI) | The study was terminated after all enrolled participants progressed. | Enrollment / accrual |
| NCT00126867 | Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to Capecitabine… | — | terminated | Aug 5, 2005 | AHS Cancer Control Alberta | Insufficient accrual and no funding | Enrollment / accrual |
| NCT01445054 | 111 Indium CHX-A DTPA Trastuzumab (Indium-Herceptin) for Imaging Breast Cancer | Early Phase 1 | terminated | Oct 3, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02883790 | Effects of Somnage® in the Management on Sleep and Mood in Cancer Patients | N/A | terminated | Aug 30, 2016 | Helsinn Healthcare SA | Low enrolment rate | Enrollment / accrual |
| NCT02402036 | A Biomarker Study in Patients Getting Regorafenib for Metastatic Colorectal Cancer | Phase 2 | terminated | Mar 30, 2015 | Georgetown University | not stated | Not stated |
| NCT00267787 | Molecular Genetic and Pathological Studies of Anal Tumors | — | terminated | Dec 21, 2005 | Stanford University | not stated | Not stated |
| NCT03014284 | Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and… | — | withdrawn | Jan 9, 2017 | The University of Texas Health Science Center at San Antonio | Military collaborator sample supplier was transferred, no samples obtained | Other (stated, no rule matched) |
| NCT02216149 | Effects of S-1 and Capecitabine on Coronary Artery Blood Flow(FluoHeart) | Phase 2 | terminated | Aug 13, 2014 | Heikki Joensuu | Slow accrual | Enrollment / accrual |
| NCT03073473 | Evaluation of the NantHealth GPS Cancer Test in Patients With Advanced Cancers | — | terminated | Mar 8, 2017 | Cota Inc. | Poor accrual | Enrollment / accrual |
| NCT00845039 | A Study of Irinotecan and Cetuximab With or Without IMC-A12 for Treatment of Participants…(FC-4) | Phase 2 | terminated | Feb 16, 2009 | Eli Lilly and Company | Study terminated early 22Feb2010 with only 4 participants due to business reasons. | Sponsor / business decision |
| NCT03306966 | Assessing the Safety and Performance of the Endoscopic Linear Cutter Stapler and Reloads… | — | withdrawn | Oct 11, 2017 | Duomed | Design modification | Other (stated, no rule matched) |
| NCT00827580 | Eniluracil Hand Foot Syndrome | Phase 1 | terminated | Jan 23, 2009 | West Virginia University | not stated | Not stated |
| NCT01919541 | Mechanistic Prehabilitation | N/A | withdrawn | Aug 9, 2013 | Franco Carli | difficulty in recruiting patients | Enrollment / accrual |
| NCT01284504 | Effect of Celecoxib on Perioperative Inflammatory Response in Colon Cancer | N/A | terminated | Jan 27, 2011 | Stanford University | low accrual rate; the only participant withdrew after signing consent | Enrollment / accrual |
| NCT02110953 | Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal… | Phase 1 | terminated | Apr 10, 2014 | Fox Chase Cancer Center | IRB study closure by investigator due to low enrollment | Investigator |
| NCT01934179 | Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal… | — | terminated | Sep 4, 2013 | Fox Chase Cancer Center | Low Accrual Rate | Enrollment / accrual |
| NCT02399631 | Enhanced Recovery Program After Laparoscopic Colon Cancer Surgery | N/A | terminated | Mar 26, 2015 | Kyungpook National University Hospital | not stated | Not stated |
| NCT01729923 | A Trial of Maintenance ADAPT Therapy With Capecitabine and Celecoxib in Patients With…(ADAPT) | Phase 2 | terminated | Nov 20, 2012 | University of Washington | Funding ended | Funding |
| NCT01012362 | Study of Pazopanib and Ixabepilone in Patients With Solid Tumors | Phase 1 | terminated | Nov 13, 2009 | Masonic Cancer Center, University of Minnesota | PI left institution. | Investigator |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Jan 9, 2023source: clinicaltrials