Clinical trial · Observational
Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis
NCT03014284CI-TRIAL-00034891withdrawnClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Military collaborator sample supplier was transferred, no samples obtained
Summary
Brief summary (as posted)
This is a simple tissue collection study with no therapeutic intent. Colon tissues will be taken from standard of care procedures. Tissues will be tested for their functions, expression of immune co-signaling molecules and reactions to transduction with recombinant Listeria vectors to assess effects on expression of B7-H1 and cytokines.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colitis | — | UNRESOLVED | — |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Expression of B7-H1
- timeFrame
- Baseline tissue collection
- description
- To assess the ability of recombinant Listeria to modulate B7-H1 in human colonic tissues
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * Able to provide informed consent (or have consent provided through a guardian) * No immune-modulating drug use during study or within 30 days prior to enrollment * Having colon material collected as part of standard of care Exclusion Criteria: * Unable to provide informed consent (or have consent provided through a guardian) * Not having colon material collected as part of standard of care
References
Publications (0)
Data not yet available
No reference posted for this study.