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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
163 stopped studies mapped to Malignant Colon Neoplasm and descendants · 88% state a reason
Over the 163 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computed
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03623464 | RCT of Mobile Apps & FitBit v. Usual Care | N/A | suspended | Aug 9, 2018 | Weill Medical College of Cornell University | Study is paused for interim analysis. | Efficacy / futility |
| NCT04031469 | A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease | — | suspended | Jul 24, 2019 | ProgenaBiome | Administrative | Other (stated, no rule matched) |
| NCT06929338 | xDRIVE in Metastatic Colorectal Cancer | — | withdrawn | Apr 16, 2025 | First Ascent Biomedical Inc. | Unable to finalize study agreements | Other (stated, no rule matched) |
| NCT03745326 | Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor… | Phase 1 / Phase 2 | terminated | Nov 19, 2018 | National Cancer Institute (NCI) | Study was closed due to lack of accrual and study outcomes overlapped with another protocol's… | Enrollment / accrual |
| NCT04955808 | Biospecimen Collection in Identifying Genetic Changes in Patients With Breast, Prostate,… | — | suspended | Jul 9, 2021 | National Cancer Institute (NCI) | Due to slow accrual on this trial, we will allow sites time to work on close-out procedures and… | Enrollment / accrual |
| NCT05861947 | A Phase 1 Clinical Trial of AUR106 in Patients With Relapsed Advanced Malignancies(JIVAN) | Phase 1 | terminated | May 17, 2023 | Aurigene Discovery Technologies Limited | Patient recruitment problems | Enrollment / accrual |
| NCT06281925 | Cryotherapy & Oxaliplatin | N/A | suspended | Feb 28, 2024 | NYU Langone Health | Study paused to enrollment | Enrollment / accrual |
| NCT06625515 | First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or… | Phase 1 | terminated | Oct 3, 2024 | Accent Therapeutics | The study was terminated by sponsor based on the adverse event profile. | Safety / toxicity |
| NCT05983367 | A Study to Investigate Ompenaclid Combined With FOLFIRI Plus Bevacizumab in… | Phase 2 | terminated | Aug 9, 2023 | Inspirna, Inc. | At the time of the primary analysis, results did not meet the primary endpoint | Other (stated, no rule matched) |
| NCT02724202 | Curcumin in Combination With 5FU for Colon Cancer | Early Phase 1 | terminated | Mar 31, 2016 | Baylor Research Institute | PI-Initiated study; PI requested closure | Other (stated, no rule matched) |
| NCT05062889 | Exploiting Circulating Tumour DNA to Intensify the Postoperative Treatment Resected Colon…(ERASE-CRC) | Phase 2 | suspended | Sep 30, 2021 | Gruppo Oncologico del Nord-Ovest | due to earlier termination of the agreement between the Sponsor and Central Laboratory for… | Enrollment / accrual |
| NCT06457997 | A Study of PHN-010 in Patients With Advanced Solid Tumors | Phase 1 | terminated | Jun 13, 2024 | Pheon Therapeutics | The study was terminated by Sponsor for strategic reasons. | Sponsor / business decision |
| NCT05329870 | Does Genetic Susceptibility for Bleeding Affect Quantitative Faecal Immunochemical Test… | — | withdrawn | Apr 15, 2022 | University of Edinburgh | never started due to funding/staffing issues | Funding |
| NCT05169437 | Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors(PAVO) | Phase 2 | terminated | Dec 27, 2021 | Tempus AI | Recruitment challenges | Enrollment / accrual |
| NCT03765736 | Genetic Testing in Screening Patients With Metastatic or Unresectable Colon or Rectal… | — | terminated | Dec 5, 2018 | Academic and Community Cancer Research United | Low accrual | Enrollment / accrual |
| NCT02784795 | A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors | Phase 1 | terminated | May 27, 2016 | Eli Lilly and Company | The study was terminated due to business considerations | Sponsor / business decision |
| NCT04964297 | Evaluation of Ability to Detect Bowel Gas During Laparoscopic Right Colectomy With… | N/A | terminated | Jul 16, 2021 | Weill Medical College of Cornell University | Need for device upgrade. | Other (stated, no rule matched) |
| NCT02467582 | Adjuvant Aspirin Treatment for Colon Cancer Patients | Phase 3 | terminated | Jun 10, 2015 | Swiss Cancer Institute | Board decision in 2020 due to lack of financial funding. | Funding |
| NCT04108481 | Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer(iRE-C) | Phase 1 | terminated | Sep 30, 2019 | University of Iowa | DSMC-directed closure | Other (stated, no rule matched) |
| NCT01372696 | Endoscopic Characteristics of Colonic Tumours(C-LST) | N/A | withdrawn | Jun 14, 2011 | Professor Michael Bourke | study abandoned | Other (stated, no rule matched) |
| NCT05179837 | Endoscopic Optical Coherence Tomography for Screening and Diagnosis of Colorectal… | N/A | terminated | Jan 5, 2022 | Washington University School of Medicine | Low accrual | Enrollment / accrual |
| NCT04213794 | Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for…(TOASTIT) | Early Phase 1 | terminated | Dec 30, 2019 | Mayo Clinic | slow accrual | Enrollment / accrual |
| NCT03764137 | Imaging with [89Zr]Panitumumab-PET/MRI in Patients with Newly Diagnosed Colorectal Cancer(Panitumumab) | Phase 1 / Phase 2 | withdrawn | Dec 4, 2018 | University of Alabama at Birmingham | Study was not able to enroll any subjects | Enrollment / accrual |
| NCT04975256 | Adagrasib in Combination With BI 1701963 in Patients With Cancer (KRYSTAL 14) | Phase 1 | terminated | Jul 23, 2021 | Mirati Therapeutics Inc. | The decision was made to terminate this study to further enrollment, as of 08 March 2022. The… | Enrollment / accrual |
| NCT04093557 | Improving Outpatient Colonoscopy Bowel Prep With the Orton Score | N/A | withdrawn | Sep 18, 2019 | University of Virginia | Not enough funding for research coordinator. | Funding |
| NCT05427344 | Effectiveness of Aquatic Exercise on Fatigue, Neuropathy and Quality of Life Among Cancer… | N/A | withdrawn | Jun 22, 2022 | Tel Aviv University | The study was stopped because we were unable to recruit participants as planned. Therefore, it was… | Enrollment / accrual |
| NCT06575725 | Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the… | Phase 2 | withdrawn | Aug 28, 2024 | City of Hope Medical Center | Abandoned 9/23/24 | Other (stated, no rule matched) |
| NCT02980029 | TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial. | Phase 1 | terminated | Dec 2, 2016 | Mark Evers | Study was terminated by the PRMC for low accrual | Enrollment / accrual |
| NCT04488159 | Immunoscore As Decision Guidance for Adjuvant Chemotherapy in Colon Cancer(iMAGINE) | Phase 3 | withdrawn | Jul 27, 2020 | Johannes Laengle, MD, PhD | Lack of funding. | Funding |
| NCT05356897 | Tucatinib Combined with Trastuzumab and TAS-102 for the Treatment of HER2 Positive… | Phase 2 | withdrawn | May 2, 2022 | Academic and Community Cancer Research United | no sites were regulatory ready and the SC took the study to a different group. | Other (stated, no rule matched) |
| NCT05672342 | Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy… | Early Phase 1 | withdrawn | Jan 5, 2023 | City of Hope Medical Center | withdrawn | Other (stated, no rule matched) |
| NCT03127098 | QUILT-3.040: ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D)) Vaccine in Combination With ALT-803… | Phase 1 / Phase 2 | terminated | Apr 25, 2017 | NantCell, Inc. | The study was terminated before any dose escalation occurred in order to pursue other studies… | Other (stated, no rule matched) |
| NCT04231526 | Pembrolizumab in Early Stage Colon Cancer | Phase 2 | withdrawn | Jan 18, 2020 | University of Chicago | unable to accrue | Enrollment / accrual |
| NCT01855607 | Topical Menthol for the Treatment of Chemotherapy Induced Peripheral Neuropathy | Phase 2 | terminated | May 16, 2013 | Columbia University | Poor enrollment | Enrollment / accrual |
| NCT03631641 | Nivolumab in Preventing Colon Adenomas in Participants With Lynch Syndrome and a History… | Phase 2 | terminated | Aug 15, 2018 | John Hays | Sponsor decision | Sponsor / business decision |
| NCT05471401 | GI Organ Tracking Via Balloon Applicators | N/A | withdrawn | Jul 22, 2022 | Washington University School of Medicine | Low accrual | Enrollment / accrual |
| NCT05900648 | Regorafenib and XmAb20717 in Treatment of High-risk Patients With Colorectal Cancer With… | Phase 2 | withdrawn | Jun 12, 2023 | M.D. Anderson Cancer Center | 0 participant accrual | Enrollment / accrual |
| NCT04731441 | Exercise Intervention Prior to CRS-HIPEC: Feasibility & Impact | N/A | terminated | Feb 1, 2021 | Milton S. Hershey Medical Center | Difficulty enrolling and we lost exercise specialist | Enrollment / accrual |
| NCT05310565 | The Effects of Chiropractic in Adults With Colon Cancer(CCX) | N/A | withdrawn | Apr 5, 2022 | Life University | Low recruitment rate | Enrollment / accrual |
| NCT01904968 | Impact of Methylation Alterations in Colon Cancer: Epidemiology and Prognosis | — | withdrawn | Jul 22, 2013 | Centre Hospitalier Universitaire Dijon | not stated | Not stated |
| NCT04518449 | Medial Border of Laparoscopic D3 Lymphadenectomy for Right Colon Cancer | — | withdrawn | Aug 19, 2020 | Shanghai Minimally Invasive Surgery Center | no funds | Funding |
| NCT04274790 | Impact of 5-Fluorouracil (5-FU) on Cancer Cells From Liver Metastases of Colon Cancer(FLUORIB) | — | withdrawn | Feb 18, 2020 | Centre Leon Berard | Lack of funding | Funding |
| NCT04812743 | Colorectal Health Research Champions | N/A | terminated | Mar 24, 2021 | Virginia Commonwealth University | End of grant funding | Funding |
| NCT01605318 | Study of Labetuzumab Govitecan in Participants With Metastatic Colorectal Cancer | Phase 1 / Phase 2 | terminated | May 24, 2012 | Gilead Sciences | not stated | Not stated |
| NCT01769222 | Ipilimumab and Local Radiation for Selected Solid Tumors | Phase 1 | terminated | Jan 16, 2013 | Stanford University | Planned Future Study | Other (stated, no rule matched) |
| NCT02519140 | Assessing How the Viscosity of Submucosal Gel Injections Helps With Endoscopic Mucosal… | Phase 3 | withdrawn | Aug 10, 2015 | Antonios Likourezos | not stated | Not stated |
| NCT03592641 | Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal… | Phase 2 | terminated | Jul 19, 2018 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT01347645 | Irinotecan Plus E7820 Versus FOLFIRI in Second-Line Therapy in Patients With Locally… | Phase 1 / Phase 2 | terminated | May 4, 2011 | Eisai Inc. | The study was terminated by the Sponsor due to E7820 plus irinotecan being potentially inferior to… | Other (stated, no rule matched) |
| NCT04882423 | Vegetable Intake Effect on Heterocyclic Amine Metabolism | N/A | terminated | May 12, 2021 | Masonic Cancer Center, University of Minnesota | PI left the university | Investigator |
| NCT01239095 | Oral Green Tea Extract and Milk Thistle Extract to Colorectal Cancer Patients Undergoing… | Phase 1 | terminated | Nov 11, 2010 | Richard Whelan | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 hours agoSource updated Sep 28, 2026source: clinicaltrials