Publication
Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (10)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 10
- cancerMalignant Colorectal Neoplasmcivic_curation1.00
- drugAspirincivic_curation1.00
- genePIK3CAcivic_curation1.00
- genePIK3R1civic_curation1.00
- genePTENcivic_curation1.00
- variantPIK3CA Exon 10 Mutationcivic_curation1.00
- variantPIK3CA Exon 21 Mutationcivic_curation1.00
- variantPIK3CA Mutationcivic_curation1.00
- variantPIK3R1 Mutationcivic_curation1.00
- variantPTEN Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 40961426
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PIK3CA Exon 10 Mutation + PIK3CA Exon 21 Mutation1 | ||||||||
| Aspirin | Malignant Colorectal NeoplasmCURATED_BROADER | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID12601In a randomized double-blind placebo-controlled biomarker-selected adjuvant study (ALASCCA, NCT02647099; colorectal carcinoma; n = 626; group A: PIK3CA exon 9/20, n = 314), aspirin 160 mg daily (group… (full text at CIViC) PMID 40961426 · Martling et al., 2025 · Open in CIViC | civic |
| PIK3CA Mutation + PIK3R1 Mutation + PTEN MutationPIK3CAPTENPIK3R11 | ||||||||
| Aspirin | Malignant Colorectal NeoplasmCURATED_BROADER | Predictive | B | Supports Sensitivity Response | 4 | accepted | EID12602In a randomized, double blind, placebo controlled adjuvant trial in colorectal carcinoma with PI3K pathway mutations (ALASCCA, NCT02647099; group B n = 312), aspirin 160 mg daily (group B n = 156) for… (full text at CIViC) PMID 40961426 · Martling et al., 2025 · Open in CIViC | civic |