Publication
Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (21)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 21
- geneTP53civic_curation1.00
- variantTP53 C124Rcivic_curation1.00
- variantTP53 C135Wcivic_curation1.00
- variantTP53 E68Gcivic_curation1.00
- variantTP53 F270Scivic_curation1.00
- variantTP53 G245Scivic_curation1.00
- variantTP53 G266Ecivic_curation1.00
- variantTP53 G266Vcivic_curation1.00
- variantTP53 H115Ycivic_curation1.00
- variantTP53 H178Pcivic_curation1.00
- variantTP53 H179Rcivic_curation1.00
- variantTP53 L111Rcivic_curation1.00
- variantTP53 L139Ncivic_curation1.00
- variantTP53 P152Lcivic_curation1.00
- variantTP53 R156Hcivic_curation1.00
- variantTP53 R158Gcivic_curation1.00
- variantTP53 R158Hcivic_curation1.00
- variantTP53 R175Hcivic_curation1.00
- variantTP53 R181Pcivic_curation1.00
- variantTP53 R249Scivic_curation1.00
- variantTP53 V272Gcivic_curation1.00
Curated evidence
Evidence citing this paper (69)
50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 10519380
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 R213Q1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10570Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R213Q originally identified in glioblastoma from a glioma cell line. Should the mutant be dominant-negative (DN), TP53 will n… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R248Q1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | submitted | EID10535Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R248Q originally identified in glioblastoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R249S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10540Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R249S. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R273C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | submitted | EID10537Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R273C originally identified in glioblastoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R273H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | submitted | EID10536Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R273H originally identified in anaplastic astrocytoma. Should the mutant be dominant-negative (DN), TP53 will not bind and tr… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R273L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | submitted | EID10538Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R273L originally identified in an oral lesion. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R282W1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10580Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R282W originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R306E1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10609Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R306E. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R337P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10582Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R337P originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R337S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10610Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R337S. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 S127Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10587Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant S127Y. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 S227C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10603Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant S227C. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 V173G1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10564Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant V173G originally identified in glioblastoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 V173M1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10597Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant V173M. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 V197L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10569Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant V197L originally identified in glioblastoma from a glioma cell line. Should the mutant be dominant-negative (DN), TP53 will n… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 V272G1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10577Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant V272G originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 Y163C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10563Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant Y163C originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 Y220C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10571Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant Y220C originally identified in anaplastic astrocytoma. Should the mutant be dominant-negative (DN), TP53 will not bind and tr… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 Y220H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10572Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant Y220H originally identified in CNS lymphoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |