Publication
Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (21)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 21
- geneTP53civic_curation1.00
- variantTP53 C124Rcivic_curation1.00
- variantTP53 C135Wcivic_curation1.00
- variantTP53 E68Gcivic_curation1.00
- variantTP53 F270Scivic_curation1.00
- variantTP53 G245Scivic_curation1.00
- variantTP53 G266Ecivic_curation1.00
- variantTP53 G266Vcivic_curation1.00
- variantTP53 H115Ycivic_curation1.00
- variantTP53 H178Pcivic_curation1.00
- variantTP53 H179Rcivic_curation1.00
- variantTP53 L111Rcivic_curation1.00
- variantTP53 L139Ncivic_curation1.00
- variantTP53 P152Lcivic_curation1.00
- variantTP53 R156Hcivic_curation1.00
- variantTP53 R158Gcivic_curation1.00
- variantTP53 R158Hcivic_curation1.00
- variantTP53 R175Hcivic_curation1.00
- variantTP53 R181Pcivic_curation1.00
- variantTP53 R249Scivic_curation1.00
- variantTP53 V272Gcivic_curation1.00
Curated evidence
Evidence citing this paper (69)
50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 10519380
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 A138K1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10589Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant A138K. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 A161D1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10592Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant A161D. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 A161G1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10562Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant A161G originally identified in anaplastic astrocytoma. Should the mutant be dominant-negative (DN), TP53 will not bind and tr… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 A161V1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10594Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant A161V. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 A347G1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10583Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant A347G originally identified in glioblastoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 A83E1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10584Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant A83E. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/pi… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 A86E1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10586Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant A86E. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/pi… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 A86T1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10585Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant A86T. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/pi… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 C124R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10556Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant C124R originally identified in anaplastic astrocytoma. Should the mutant be dominant-negative (DN), TP53 will not bind and tr… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 C135F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10588Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant C135F. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 C135W1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10557Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant C135W originally identified in glioblastoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 C176F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10567Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant C176F originally identified in an oral lesion. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 C176S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10565Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant C176S originally identified in glioblastoma from a glioma cell line. Should the mutant be dominant-negative (DN), TP53 will n… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 C176Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10566Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant C176Y originally identified in an oral lesion. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 C275F1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10579Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant C275F originally identified in glioblastoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 C275Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10578Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant C275Y originally identified in glioblastoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 C277Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10606Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant C277Y. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 D281Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10607Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant D281Y. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 E68G1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10541Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant E68G originally identified in anaplastic astrocytoma. Should the mutant be dominant-negative (DN), TP53 will not bind and tra… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 F270S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10576Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant F270S originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 G245D1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | submitted | EID10533Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant G245D originally identified in an oral lesion. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 G245S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10532Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant G245S originally identified in an oral lesion. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 G262C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10604Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant G262C. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 G266E1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10575Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant G266E originally identified in glioblastoma from a glioma cell line. Should the mutant be dominant-negative (DN), TP53 will n… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 G266R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10573Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant G266R originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 G266V1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10574Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant G266V originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 H115Y1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10555Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant H115Y originally identified in anaplastic astrocytoma from a glioma cell line. Should the mutant be dominant-negative (DN), T… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 H168Q1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10596Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant H168Q. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 H168R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10595Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant H168R. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 H178P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10529Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant H178P originally identified in glioblastoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 H179R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10530Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant H179R originally identified in an oral lesion. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 H193L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10568Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant H193L originally identified in an oral lesion. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 K305N1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10608Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant K305N. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 L111R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10554Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant L111R originally identified in anaplastic astrocytoma. Should the mutant be dominant-negative (DN), TP53 will not bind and tr… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 L139N1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10558Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant L139N originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 L305M1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10581Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant L305M originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 M246R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | submitted | EID10534Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant M246R originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 P152L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10559Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant P152L originally identified in an oral lesion. Should the mutant be dominant-negative (DN), TP53 will not bind and transacti… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 P177S1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | submitted | EID10539Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant P177S. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 P190H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10599Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant P190H. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 Q144Q1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10590Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant Q144Q. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 Q167R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10593Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant Q167R. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R156H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10528Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R156H originally identified in an oral lesion. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiv… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R158C1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10591Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R158C. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R158G1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10560Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R158G originally identified in anaplastic astrocytoma. Should the mutant be dominant-negative (DN), TP53 will not bind and tr… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R158H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | accepted | EID10561Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R158H originally identified in glioblastoma. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivat… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R175H1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10527Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R175H originally identified in anaplastic astrocytoma. Should the mutant be dominant-negative (DN), TP53 will not bind and tr… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R181L1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10598Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R181L. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R181P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Dominant Negative | 3 | accepted | EID10531Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R181P originally identified in breast cancer. Should the mutant be dominant-negative (DN), TP53 will not bind and transactiva… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |
| TP53 R196Q1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Does Not Support Dominant Negative | 3 | submitted | EID10601Yeast strain yIG397 was cultured to express both wild-type (WT) and mutant R196Q. Should the mutant be dominant-negative (DN), TP53 will not bind and transactivate the ADE2 protein, resulting in red/p… (full text at CIViC) PMID 10519380 · Marutani et al., 1999 · Open in CIViC | civic |