USH2A

usherin

Identifier: CI-GENE-00038102
Entity page: /gene/USH2A ↗
Edges: 49

Neighbours: 27 cancers15 variants
Drawn: 42 of 42 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
USH2A has variant …HAS_VARIANTderived15 of 22show all (up to 200)
→ has variant	NM_206933.4(USH2A):c.10182+27C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_206933.4(USH2A):c.10585+211A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0

USH2A altered in cohorts of …ALTERED_INderived27 of 27show fewer
→ altered in cohorts of	Breast Invasive Carcinoma, NOS 803 / 1,098 cases (73 %) · ssm · TCGA-BRCA	—	—	Breast Invasive Carcinoma, NOS	1	Observed	gdc	graph →
→ altered in cohorts of	Lung Adenocarcinoma 402 / 573 cases (70 %) · ssm · TCGA-LUAD · largest of 11 cohorts	—	—	Lung Adenocarcinoma	11	Observed	gdc	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 74 / 126 cases (59 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 286 / 559 cases (51 %) · ssm · TCGA-UCEC · largest of 5 cohorts	—	—	Endometrial Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 40 / 83 cases (48 %) · ssm · cscc_ucsf_2021 · largest of 3 cohorts	—	—	Skin Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 44 / 120 cases (37 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 390 / 1,144 cases (34 %) · ssm · nsclc_tcga_broad_2016 · largest of 3 cohorts	—	—	Lung Non-Small Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 160 / 484 cases (33 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 6 cohorts	—	—	Lung Squamous Cell Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 141 / 469 cases (30 %) · ssm · skcm_tcga_gdc · largest of 9 cohorts	—	—	Cutaneous Melanoma	9	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 32 / 144 cases (22 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 29 / 158 cases (18 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 69 / 429 cases (16 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 29 / 185 cases (16 %) · ssm · esca_tcga · largest of 2 cohorts	—	—	Esophageal Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 38 / 247 cases (15 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 79 / 518 cases (15 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 59 / 478 cases (12 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 63 / 515 cases (12 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 33 / 291 cases (11 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Cervical Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 95 / 1,015 cases (9.4 %) · ssm · crc_sysucc_2022 · largest of 5 cohorts	—	—	Colorectal Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 43 / 494 cases (8.7 %) · ssm · hcc_clca_2024 · largest of 4 cohorts	—	—	Hepatocellular Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 23 / 297 cases (7.7 %) · ssm · mbn_sfu_2023	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 48 / 629 cases (7.6 %) · ssm · difg_glass · largest of 3 cohorts	—	—	Diffuse Glioma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 71 / 961 cases (7.4 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 170 / 2,433 cases (7.0 %) · ssm · brca_metabric · largest of 6 cohorts	—	—	Invasive Breast Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 31 / 444 cases (7.0 %) · ssm · prad_su2c_2019	—	—	Prostate Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 32 / 474 cases (6.8 %) · ssm · blca_msk_tcga_2020 · largest of 5 cohorts	—	—	Bladder Urothelial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	High-Grade Serous Ovarian Cancer 32 / 523 cases (6.1 %) · ssm · ov_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	High-Grade Serous Ovarian Cancer	4	Observed	cbioportal	graph →

USH2A altered in cohorts of …ALTERED_INderived27 of 27show fewer

→ altered in cohorts of

Breast Invasive Carcinoma, NOS

803 / 1,098 cases (73 %) · ssm · TCGA-BRCA

—

Breast Invasive Carcinoma, NOS

Observed

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