RYR1

ryanodine receptor 1

Identifier: CI-GENE-00029700
Entity page: /gene/RYR1 ↗
Edges: 5,286

Neighbours: 24 cancers15 variants
Drawn: 39 of 39 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
RYR1 has variant …HAS_VARIANTderived15 of 5,262show all (up to 200)
→ has variant	NM_000540.3(RYR1):c.10007A>G (p.Lys3336Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000540.3(RYR1):c.10009C>T (p.Arg3337Trp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0

RYR1 altered in cohorts of …ALTERED_INderived24 of 24show fewer
→ altered in cohorts of	Skin Basal Cell Carcinoma 56 / 126 cases (44 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 30 / 83 cases (36 %) · ssm · cscc_ucsf_2021 · largest of 2 cohorts	—	—	Skin Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 37 / 158 cases (23 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 109 / 469 cases (23 %) · ssm · skcm_tcga_gdc · largest of 7 cohorts	—	—	Cutaneous Melanoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 23 / 120 cases (19 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 98 / 517 cases (19 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 45 / 247 cases (18 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 26 / 144 cases (18 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 83 / 484 cases (17 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Lung Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 95 / 566 cases (17 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 7 cohorts	—	—	Lung Adenocarcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 67 / 429 cases (16 %) · ssm · coad_tcga_gdc · largest of 4 cohorts	—	—	Colon Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 177 / 1,144 cases (15 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 62 / 518 cases (12 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 51 / 478 cases (11 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 101 / 1,015 cases (10.0 %) · ssm · crc_sysucc_2022 · largest of 6 cohorts	—	—	Colorectal Adenocarcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 54 / 629 cases (8.6 %) · ssm · difg_glass · largest of 2 cohorts	—	—	Diffuse Glioma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 41 / 494 cases (8.3 %) · ssm · hcc_clca_2024 · largest of 4 cohorts	—	—	Hepatocellular Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 39 / 474 cases (8.2 %) · ssm · blca_msk_tcga_2020 · largest of 5 cohorts	—	—	Bladder Urothelial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 29 / 379 cases (7.7 %) · ssm · brca_mbcproject_2022	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 34 / 515 cases (6.6 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 62 / 961 cases (6.5 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 28 / 444 cases (6.3 %) · ssm · prad_su2c_2019	—	—	Prostate Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 46 / 755 cases (6.1 %) · ssm · mbn_mdacc_2013	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Pancreatic Adenocarcinoma 21 / 383 cases (5.5 %) · ssm · paad_qcmg_uq_2016	—	—	Pancreatic Adenocarcinoma	1	Observed	cbioportal	graph →

RYR1 altered in cohorts of …ALTERED_INderived24 of 24show fewer

→ altered in cohorts of

Skin Basal Cell Carcinoma

56 / 126 cases (44 %) · ssm · bcc_unige_2016

—

Skin Basal Cell Carcinoma

Observed

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