RAF1

Raf-1 proto-oncogene, serine/threonine kinase

Identifier: CI-GENE-00022885
Entity page: /gene/RAF1 ↗
Edges: 38

Neighbours: 5 cancers25 variants7 drugs
Drawn: 37 of 37 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
RAF1 associated with …ASSOCIATED_WITH6 of 6
→ associated with	Cutaneous Melanomacancer	supports	B	Cutaneous Melanoma	1	Curated	civic	graph →
→ associated with	Melanomacancer_family 4 source records aggregated	supports	C

RAF1 targets …TARGETS7 of 7
← targets	Tovorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sorafenib Tosylatesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Regorafenib Anhydroussmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Regorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pan-RAF Inhibitor LY3009120small_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Belvarafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

RAF1 targets …TARGETS7 of 7

← targets

Tovorafenibsmall_molecule

—

INHIBITOR

—

Curated

RAF1 has variant …HAS_VARIANTderived25 of 25show fewer
→ has variant	Fusionfusion 2 accepted CIViC evidence items	—	—	Melanoma,Acral Lentiginous Melanoma	2	Curated	civic	graph →
→ has variant	Amplificationamplification 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Spindle Cell Sarcoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	R391WSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	S257LSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.1171A>T (p.Arg391Trp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.1193G>T (p.Arg398Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.1272C>T (p.Cys424=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.1721A>G (p.Tyr574Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.1830A>G (p.Gln610=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.581+262A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.582-137A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.673C>T (p.Pro225Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.770C>T (p.Ser257Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.776C>G (p.Ser259Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.779C>G (p.Thr260Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.782C>A (p.Pro261His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.94A>G (p.Ile32Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002880.4(RAF1):c.991-118A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	T303ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

Radial view

Every edge, grouped by relationship

Paths