Variant · Snv
RAF1 S257L
CI-VAR-00004042Explore in graph →CIViC 5484
Curated evidence
Evidence by cancer (1 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24569458
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Malignant Neoplasm1 | ||||||||
| RAF1 S257L | (oncogenic) | Oncogenic | D | Supports Oncogenicity | 4 | accepted | EID12991RAF1 p.S257L (and p.S259A) induced anchorage-independent growth and increased MEK/ERK phosphorylation in AALE and NIH-3T3 cells in a sorafenib- and trametinib-sensitive manner. Supporting data is foun… (full text at CIViC) PMID 24569458 · Imielinski et al., 2014 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available
No ClinVar interpretation attached to this variant.