RAF1 NM_002880.4(RAF1):c.770C>T (p.Ser257Leu)

CI-VAR-00006290Explore in graph →p.Ser257LeuNM_002880.4:c.770C>TClinVar 13957 rs80338796

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
13957	Pathogenic	reviewed by expert panel	3	Noonan syndrome 5; LEOPARD syndrome 2; Noonan syndrome with multiple lentigines; Noonan syndrome; RASopathy; Dilated cardiomyopathy 1NN; Noonan syndrome 1; RAF1-related disorder; Cardiovascular phenotype; Noonan syndrome and Noonan-related syndrome; Embryonal rhabdomyosarcoma	germline/somatic	47	Apr 03, 2017	clinvar