Variant · Snv
RAF1 R391W
CI-VAR-00003846Explore in graph →ENST00000251849.4:c.1171A>TCIViC 1680
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27273450
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Melanoma1 | ||||||||
| RAF1 R391W | Vemurafenib | Predictive | D | Supports Resistance | — | submitted | EID4824In an in vitro study, M375 and M238 cell lines expressing RAF1 (CRAF) R391W demonstrated resistant to vemurafenib treatment compared to M397 cells expressing BRAF V600E (a known vemurafenib sensitizin… (full text at CIViC) PMID 27273450 · Atefi et al., 2016 · Open in CIViC | civic |
| Unmapped disease1unmapped disease | ||||||||
| RAF1 R391W | (functional) | Functional | D | Supports Gain Of Function | 3 | accepted | EID11044RAF1 (CRAF) R391W was observed in a melanoma patient from which cell line M375 was derived (wild-type for BRAF and NRAS). RAF1 R391W expressed in 293T cells showed increased phosphorylation of MEK and… (full text at CIViC) PMID 27273450 · | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available